Objective: 1. Selecting the key problems in medicine - I. Diagnostic problems, II. Didactic and training problems of medical education, III. Economical problems, IV. Communications technologies problems, V. Psychological problems, VI. Social problems, VII. Strategic problems. 2. Outline ways to optimal solution of these problems. Materials and Methods: Innovative intellectual approach to medical diagnostic decision-making has been sugges-ted. Knowledge levels and didactic systems, its limitations have been described. The methodologies and computerized technologies are tools to overcome the obstacles. Results: Series of didactic experiments were carried out with the purpose to evaluate comparatively conventional and offered innovative methods of diagnostics and professional training shows significant advantages of the innovations. Conclusion: The above mentioned problems can be solved successfully by computerized diagnostics based on algorithmical evidence-based approach to disease recognizing, and mass professional education mainly based on eLearning.