Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarctionAhmet Göktuğ Ertem1, Sefa Ünal1, Tolga Han Efe2, Burak Açar1, Çağrı Yayla1, Mevlüt Serdar Kuyumcu1, Özgür Kırbaş1, Cemal Köseoğlu3, Mehmet Kadri Akboğa1, Kadriye Gayretli Yayla2, Serkan Gökaslan1, Sinan Aydoğdu1
1Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey
2Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital; Ankara-Turkey
3Department of Cardiology, Tokat State Hospital; Tokat-Turkey
Objective: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relation- ship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.Keywords: acute coronary syndrome, adropin, SYNTAX score
Methods: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.
Results: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.9981.000; p=0.007).
Conclusion: Adropin could be an alternative blood sample value for predicting severity of CAD. (Anatol J Cardiol 2017; 17: 119-24)
Ahmet Göktuğ Ertem, Sefa Ünal, Tolga Han Efe, Burak Açar, Çağrı Yayla, Mevlüt Serdar Kuyumcu, Özgür Kırbaş, Cemal Köseoğlu, Mehmet Kadri Akboğa, Kadriye Gayretli Yayla, Serkan Gökaslan, Sinan Aydoğdu. Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. Anatol J Cardiol. 2017; 17(2): 119-124
Corresponding Author: Ahmet Göktuğ Ertem, Türkiye