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Predictive Value of Baseline CRP to Periprocedural Myocardial Infraction of Higher Risk Stratifications, a Retrospective Cohort Clinical Study. [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-05406 | DOI: 10.14744/AnatolJCardiol.2018.05406  

Predictive Value of Baseline CRP to Periprocedural Myocardial Infraction of Higher Risk Stratifications, a Retrospective Cohort Clinical Study.

Mingyang Yao, Linlin Zhao, Lili Wu, Wenbin Zhang, Yi Luan, Jiale Song, Guosheng Fu, Junhui Zhu
Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University

Background: It is controversial whether preprocedural elevated high sensitivity C-reactive protein (CRP) could increase the incidence of PMI of higher risk stratifications. The primary aim of this study was to evaluate whether preoperative elevated CRP level was related to the incidence of PMI in patients who underwent PCI.
Patients and methods: A total of 4,426 patients (66yrs (59, 75); 72.3% males) with normal preprocedural cardiac biomarkers were prospectively divided into two groups (elevated CRP group was defined as CRP >3 mg/L, about 30.4%). The relationship between CRP and the incidence of PMI was established by multivariate logistic regression analysis, and multivariate linear regression analysis was used to assess the correlation between CRP and the severity of myocardial injury.
Result: The incidence rates were similar between the two groups with periprocedural myocardial minor necrosis (34.23% versus 32.74%, P=0.607), but significantly differed based on the 2007 (31.25% in high CRP group versus 26.25% in low group, odds ratio [OR]: 1.19, P=0.046) and the 2012 universal PMI (19.79% versus 15.35%, OR: 1.26, P=0.023), besides, the PMI ratios increased in line with the elevation of CRP (P=0.006 for the 2007 and P=0.011 for the 2012 universal PMI). However, no significant linear relationship was found between CRP and cTnI peak post-PCI.
Conclusion: Elevated baseline CRP was an independent risk factor for the incidence of the 2007 and the 2012 universal PMI rather than minor necrosis. However, CRP may not correlate with the severity of minor myocardial necrosis in PMI patients.

Keywords: CRP, Percutaneous Coronary Intervention (PCI), Complications, PCI, Prediction;,, Periprocedural myocardial infraction (PMI)




Corresponding Author: Junhui Zhu, China


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