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Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(4): 298-302 | DOI: 10.5152/akd.2010.086  

Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats

Süleyman Oktar1, Mehmet Aydın2, Zafer Yönden3, Ergül Alçin4, Selçuk İlhan1, Ahmet Nacar5
1Fırat Üniversitesi Tıp Fakültesi, Farmakoloji Anabilim Dalı, Elazığ, Türkiye
2Department of Nuclear Medicine Faculty of Medicine, Başkent University, Ankara, Turkey
3Department of Biochemistry Faculty of Medicine, Mustafa Kemal University, Hatay
4Department of Physiology Faculty of Medicine, Fırat University, Elazığ
5Department of Histology Faculty of Medicine, Mustafa Kemal University, Hatay

Objective: Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor and antioxidant activities and attenuates inflammation and lipid peroxidation induced by ischemia-reperfusion injury. The purpose of the present study was to investigate the effects of CAPE on isoproterenol (ISO) -induced myocardial infarction. Methods: A randomized controlled experimental design was used in this study. Rats were divided into four groups and treated with saline, CAPE, ISO and ISO+CAPE. Rats were treated with CAPE (10 μmol kg/day i.p.) or saline starting 3 days before injecting ISO (150 mg /kg s.c., 24 hours). Seven days later, rats were sacrificed and the hearts were excised for biochemical analyses and microscopic examination. One-way ANOVA test with post hoc multiple comparisons using LSD method were used for statistical analysis of the data. Results: The administration of ISO alone resulted in higher myeloperoxidase (MPO) activity, lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) than in the control. The enzyme activities did not change in rat given CAPE alone. CAPE treatment prevented the increase in MPO activity and malondialdehyde, but did not affect the activities SOD and CAT enzymes. Conclusion: In light of these results, we conclude that CAPE prevents MPO-and lipid peroxidation-mediated myocardial injury via inhibition of neutrophil’s MPO activity.

Keywords: Caffeic acid phenethyl ester, isoproterenol, myeloperoxidase, myocardial infarction, lipid peroxidation, oxidative stress


Süleyman Oktar, Mehmet Aydın, Zafer Yönden, Ergül Alçin, Selçuk İlhan, Ahmet Nacar. Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats. Anatol J Cardiol. 2010; 10(4): 298-302


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