Low acylation stimulating protein levels are associated with cardiometabolic disorderssecondary to autoimmune activation?Altan Onat1, Servet Altay4, Murat Yüksel5, Yusuf Karadeniz6, Günay Can2, Hüsniye Yüksel2, Evin Ademoğlu3
1Departments of Cardiology, Cerrahpaşa Medical Faculty, İstanbul University; İstanbul-Turkey
2Public Health, Cerrahpaşa Medical Faculty, İstanbul University; İstanbul-Turkey
3Department of Biochemistry, Faculty of Medicine, İstanbul University; İstanbul-Turkey
4Department of Cardiology, Faculty of Medicine, Trakya University; Edirne-Turkey
5Department of Cardiology, Faculty of Medicine, Dicle University; Diyarbakır-Turkey
6Department of Endocrinology and Metabolism, Faculty of Medicine, Atatürk University; Erzurum-Turkey
Objective: We investigated the possible association of serum acylation stimulating protein (ASP) with cardiometabolic disorders and the evi- dence of autoimmune activation.Keywords: acylation stimulating protein, autoimmunity, type-2 diabetes, lipoprotein(a), metabolic syndrome, platelet activating factor, phospholipids
Methods: Population-based randomly selected 1024 participants were cross-sectionally and prospectively analyzed. ASP concentrations were measured with a validated ELISA kit. Correlations were sought separately in subjects with no cardiometabolic disorders (n=427) designated as healthy.
Results: ASP was positively correlated with total testosterone and inversely correlated with platelet activating factor (PAF), PAF-acetylhydro- lase (AH), in each gender, and positively correlated in healthy men with lipoprotein [Lp](a) and apolipoprotein B. Correlations of ASP with PAF values ≥22 nmol/L were abolished, contrasted to a strongly inverse one in subjects with PAF <22 nmol/L. In linear regression analyses in the whole sample, ASP was inversely associated independently with PAF and PAF-AH and, in men, positively with Lp(a) and sex hormone-binding globulin. Prevalent and (at 2.0 years follow-up) incident metabolic syndrome (MetS, n=393), diabetes (n=154), and coronary heart disease (CHD, n=171) were analyzed by sex-, age-, and Lp(a)-adjusted logistic regression, using tertiles of ASP and PAF. The lower two (<42 nmol/L) ASP tertiles were a risk factor in combined sexes for MetS and diabetes. In women, incident CHD was predicted by either reduced or elevated ASP tertiles.
Conclusion: Findings can be explained by the notion of operation of immune responses against both ASP and oxidized PAF-like lipids of Lp(a) to yield for reduced values and increased likelihood of cardiometabolic disorders. (Anatol J Cardiol 2017; 17: 97-106)
Altan Onat, Servet Altay, Murat Yüksel, Yusuf Karadeniz, Günay Can, Hüsniye Yüksel, Evin Ademoğlu. Low acylation stimulating protein levels are associated with cardiometabolic disorderssecondary to autoimmune activation?. Anatol J Cardiol. 2017; 17(2): 97-106
Corresponding Author: Altan Onat, Türkiye