ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 17 Issue : 4 Year: 2017
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Low acylation stimulating protein levels are associated with cardiometabolic disorders–secondary to autoimmune activation? [Anatol J Cardiol]
Anatol J Cardiol. 2017; 17(2): 97-106 | DOI: 10.14744/AnatolJCardiol.2016.7024  

Low acylation stimulating protein levels are associated with cardiometabolic disorders–secondary to autoimmune activation?

Altan Onat1, Servet Altay4, Murat Yüksel5, Yusuf Karadeniz6, Günay Can2, Hüsniye Yüksel2, Evin Ademoğlu3
1Departments of Cardiology, Cerrahpaşa Medical Faculty, İstanbul University; İstanbul-Turkey
2Public Health, Cerrahpaşa Medical Faculty, İstanbul University; İstanbul-Turkey
3Department of Biochemistry, Faculty of Medicine, İstanbul University; İstanbul-Turkey
4Department of Cardiology, Faculty of Medicine, Trakya University; Edirne-Turkey
5Department of Cardiology, Faculty of Medicine, Dicle University; Diyarbakır-Turkey
6Department of Endocrinology and Metabolism, Faculty of Medicine, Atatürk University; Erzurum-Turkey

Objective: We investigated the possible association of serum acylation stimulating protein (ASP) with cardiometabolic disorders and the evi- dence of autoimmune activation.
Methods: Population-based randomly selected 1024 participants were cross-sectionally and prospectively analyzed. ASP concentrations were measured with a validated ELISA kit. Correlations were sought separately in subjects with no cardiometabolic disorders (n=427) designated as “healthy.”
Results: ASP was positively correlated with total testosterone and inversely correlated with platelet activating factor (PAF), PAF-acetylhydro- lase (AH), in each gender, and positively correlated in “healthy” men with lipoprotein [Lp](a) and apolipoprotein B. Correlations of ASP with PAF values ≥22 nmol/L were abolished, contrasted to a strongly inverse one in subjects with PAF <22 nmol/L. In linear regression analyses in the whole sample, ASP was inversely associated independently with PAF and PAF-AH and, in men, positively with Lp(a) and sex hormone-binding globulin. Prevalent and (at 2.0 years’ follow-up) incident metabolic syndrome (MetS, n=393), diabetes (n=154), and coronary heart disease (CHD, n=171) were analyzed by sex-, age-, and Lp(a)-adjusted logistic regression, using tertiles of ASP and PAF. The lower two (<42 nmol/L) ASP tertiles were a risk factor in combined sexes for MetS and diabetes. In women, incident CHD was predicted by either reduced or elevated ASP tertiles.
Conclusion: Findings can be explained by the notion of operation of immune responses against both ASP and oxidized PAF-like lipids of Lp(a) to yield for “reduced” values and increased likelihood of cardiometabolic disorders. (Anatol J Cardiol 2017; 17: 97-106)

Keywords: acylation stimulating protein, autoimmunity, type-2 diabetes, lipoprotein(a), metabolic syndrome, platelet activating factor, phospholipids


Altan Onat, Servet Altay, Murat Yüksel, Yusuf Karadeniz, Günay Can, Hüsniye Yüksel, Evin Ademoğlu. Low acylation stimulating protein levels are associated with cardiometabolic disorders–secondary to autoimmune activation?. Anatol J Cardiol. 2017; 17(2): 97-106

Corresponding Author: Altan Onat, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2016 Turkish Society of Cardiology