Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic functionSadettin Selçuk Baysal1, Bahar Pirat1, Kaan Okyay1, Uğur Abbas Bal1, Melek Zekiye Uluçam1, Derya Öztuna2, Haldun Müderrisoğlu1
1Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey
2Department of Biostatistics, Faculty of Medicine, Ankara University; Ankara-Turkey
Objective: We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension.Keywords: apelin, hypertension, diastolic function
Methods: Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment.
Results: The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p>0.05 for all). Apelin concentration was significantly lower in patients with hyper- tension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p<0.05) but was not significantly associated with change in apelin concentration.
Conclusion: Apelin concentration increased significantly after 1 month of effective treatment with telmisartan or amlodipine to a similar extent. Change in apelin concentration was not associated with improvement in diastolic function. (Anatol J Cardiol 2017; 17: 125-31)
Sadettin Selçuk Baysal, Bahar Pirat, Kaan Okyay, Uğur Abbas Bal, Melek Zekiye Uluçam, Derya Öztuna, Haldun Müderrisoğlu. Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function. Anatol J Cardiol. 2017; 17(2): 125-131
Corresponding Author: Sadettin Selçuk Baysal, Türkiye