ISSN 2149-2263 | E-ISSN 2149-2271
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Neutrophil serine proteases and their endogenous inhibitors in coronary artery ectasia patients [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(1): 23-28 | DOI: 10.5152/akd.2015.6072

Neutrophil serine proteases and their endogenous inhibitors in coronary artery ectasia patients

Ruifeng Liu1, Lianfeng Chen1, Wei Wu1, Houzao Chen2, Shuyang Zhang1
1Cardiac Department, Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences And Peking Union Medical College; Beijing-china
2Peking Union Medical College Hospital (pumch), *national Laboratory Of Medical Molecular Biology, Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences And Peking Union Medical College; Beijing-china

Objective: Proteolytic enzymes possibly contribute to coronary artery ectasia (CAE). This study aimed to determine whether neutrophils, neutrophil serine proteases (NSPs), and their endogenous inhibitors participated in the pathological process of CAE.
Methods: The study consisted of 30 patients with CAE, 30 patients with coronary artery disease (CAD), and 29 subjects with normal coronary arteries (Control). The following circulating items were measured: the main NSPs, including human neutrophil elastase (HNE), cathepsin G (CG), and proteinase 3 (PR3); soluble elastin (sElastin), which was a degradation product of elastin fibres; NSP inhibitors such as α1-protease inhibitor (α1-PI), α2-macroglobulin (α2-MG), secretory leucoprotease inhibitor (SLPI), and elafin; as well as two neutrophil activation markers (myeloperoxidase and lactoferrin) and three classic neutrophil activators [tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and bacterial endotoxin].
Results: The levels of HNE, CG, and sElastin were elevated in the CAE group. The levels of α1-PI and α2-MG were also significantly increased in the CAE group. The levels of myeloperoxidase and lactoferrin were higher in the CAE group. The levels of TNF-α, IL-8, and endotoxin were unchanged in the CAE group compared with those in the CAD group.
Conclusion: Neutrophils may participate in the process of vessel extracellular matrix destruction and coronary ectasia by releasing NSPs in a non-classical manner.

Keywords: coronary artery ectasia (CAE), neutrophil serine proteases (NSPs), human neutrophil elastase (HNE), soluble elastin (sElastin), extracellular matrix (ECM)

Ruifeng Liu, Lianfeng Chen, Wei Wu, Houzao Chen, Shuyang Zhang. Neutrophil serine proteases and their endogenous inhibitors in coronary artery ectasia patients. Anatol J Cardiol. 2016; 16(1): 23-28

Corresponding Author: Ruifeng Liu, Türkiye
Manuscript Language: English


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