ISSN 2149-2263 | E-ISSN 2149-2271
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The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina [Anatol J Cardiol]
Anatol J Cardiol. 2006; 6(1): 13-17

The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina

Mustafa Yazıcı1, Sabri Demircan2, Fidovsi İbrahimli1, Emre Aksakal1, Mahmut Şahin1, Olcay Sağkan1
1Ondokuz Mayıs Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Samsun, Türkiye
2Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Objectives: The aim of this study is to compare lipoprotein (a) [Lp(a)] levels in patients with low and high risk unstable angina pectoris which is defined according to the cardiac troponin-I (Tn-I) levels and to investigate their relation with myocardial damage. Methods: From patients with chest pain; venous blood samples were collected for measuring serum Lp(a) and CRP (C-reactive protein) levels on admission and serum cTn-I levels 12 and 24 hours after admission. Fifty-nine patients with serum cTn-I levels <1.0 ng/ml were assigned as negative unstable angina group and 53 patients with serum cTn-I levels ≥1.0 ng/ml were assigned as positive unstable angi- na groups, respectively. Severity of coronary artery disease was determined by angiography in all patients. Results: Compared with cTn-I negative group, Lp(a) levels were significantly higher in cTn-I positive group (52.9±6.0 mg/dl vs 15.7±2.5 mg/dl, p<0.0001). There was a significant correlation between Lp(a) and cTn-I levels (r=0.870, p=0,0001). We could not establish any cor- relation between Lp(a) levels and Gensini score or between multiple vessel disease and LDL cholesterol levels (p>0.05). Also, there was no significant difference between cTn-I positive and negative groups with respect to Gensini score (p>0.05). Conclusion: Increased Lp(a) levels and significant relation between Lp(a) and cTn-I levels support that Lp(a) can be a risk factor for plaque destabilization and thrombosis rather than severity of coronary artery disease in patients with high risk unstable angina. Further- more, high levels of Lp(a) may be related with myocardial injury in patients with unstable angina.

Keywords: Lipoprotein(a), unstable angina, troponin-I, myocardial injury

Mustafa Yazıcı, Sabri Demircan, Fidovsi İbrahimli, Emre Aksakal, Mahmut Şahin, Olcay Sağkan. The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina. Anatol J Cardiol. 2006; 6(1): 13-17
Manuscript Language: English


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