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X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-β1/Smad3 and p38 MAPK pathway [Anatol J Cardiol]
Anatol J Cardiol. 2017; 17(5): 367-373 | DOI: 10.14744/AnatolJCardiol.2016.7438  

X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-β1/Smad3 and p38 MAPK pathway

Yunliang Wei1, Changsheng Guo1, Jingsheng Zhao1, Jun Yang2, Weiguo Yi3, Hong Liu4, Xinwei Lin2, Zhengchen Zhang5
1Departments of Cardiovascular Medicine, Drug and Equipment the 152nd Central Hospital of PLA, Pingdingshan; Henan-China
2Nephropathy, Drug and Equipment the 152nd Central Hospital of PLA, Pingdingshan; Henan-China
3Radiology, Drug and Equipment the 152nd Central Hospital of PLA, Pingdingshan; Henan-China
4Drug and Equipment the 152nd Central Hospital of PLA, Pingdingshan; Henan-China
5Department of Drug and Equipment, the 371st Central Hospital of PLA, Xinxiang; Henan-China

Objective: Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved.
Methods: Transverse aortic constriction (TAC) was conducted to induce a CHF rat model in this study. Sixty male Wistar rats were randomly assigned to six groups 28 days after TAC: sham; CHF model; Xin at concentrations of 5 ml/kg, 10 mL/kg, and 20 mL/kg; and QiLi 0.6 g/kg. After four weeks, the rats were treated with Xin (5, 10, or 20 mL/kg/d) for six weeks consecutively. At the end of the study, the cardiac function, heart weight index (HWI) and left ventricular mass index (LVMI), serum level of LDH, B-type natriuretic peptide (BNP), cTnI and CK-MB, and collagen volume fraction were studied. The expression of transforming growth factor-β1 (TGF-β1), drosophila mothers against decapentaplegic protein 3 (Smad3), and p38 mitogen activated protein kinase (p38 MAPK) were detected.
Results: The results showed that Xin treatment significantly improved cardiac function but decreased the serum level of LDH, BNP, cTnI, and CKMB of CHF rats. In addition, it reduced the HWI, LVMI, and collagen volume fraction compared with the model group. Xin treatment significantly improved cardiac function and attenuated cardiac fibrosis by suppressing the p38 MAPK and TGF-β1/Smad3 signaling pathway in CHF rats.
Conclusion: These results suggested that Xin might be a promising complementary treatment for CHF. More detailed experimental studies will be carried out in our subsequent research.

Keywords: chronic heart failure, transverse aortic constriction, TGF-1/Smad3, p38 MAPK


Yunliang Wei, Changsheng Guo, Jingsheng Zhao, Jun Yang, Weiguo Yi, Hong Liu, Xinwei Lin, Zhengchen Zhang. X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-β1/Smad3 and p38 MAPK pathway. Anatol J Cardiol. 2017; 17(5): 367-373

Corresponding Author: Jingsheng Zhao, China


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