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Initial Research of Inflammation with Its Effect on Biomechanical Strength of Involved Aorta in Type A Aortic Dissection and Ascending Thoracic Aortic Aneurysm [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-49344 | DOI: 10.14744/AnatolJCardiol.2018.49344  

Initial Research of Inflammation with Its Effect on Biomechanical Strength of Involved Aorta in Type A Aortic Dissection and Ascending Thoracic Aortic Aneurysm

Zhixuan Bai1, Jun Gu2, Yingkang Shi2, Wei Meng2
1Department of Cardiovascular Surgery,The Second Afflicated Hospital, School of Medicine, Zhejiang University
2Department of Cardiovascular Surgery, West China Hospital, Sichuan University

Backgrounds
Type A aortic dissection(AD) and ascending thoracic aortic aneurysm (AA) were both thoracic vascular disease with same initial pathology but inequable clinical features and outcomes, where local and systemic inflammation played an important part in. The authors wanted to observe and analyze differences and correlation of inflammation, aorta pathological changes and biomechanical strength between AD and AA
Methods
From August 2011 to February 2013, 20 patients with AD(AD group)and 13 patients with AA(AA group)which undergone surgical treatment were involved in this study. Blood levels of total cholesterol(TC), triglycedides(TG), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured just before surgical anesthesia. Longitudinal vessel samples of affected ascending aorta was harvested during surgery, and prepared for subsequent pathological observation, uni-axial tension test for measuring of longitudinal tensile strength (TS). Samples were also prepared for further measurement of homogenized TNF-α and IL-6 levels.
Results
The briefly baseline data got no statistical significance between two groups, and the plasma TC and TG of two group were both in normal range(P<.05). Blood and tissue homogenized levels of IL-6 and TNF-α were all significantly higher in AD than that in AA(P<.05). Pathological observation of aorta tissue showed more inflammation cells infiltration and elastic fibers destruction in AD than AA, which indicated much significant media degeneration. Uni-axial tensile tests showed that longitudinal TS were significant lower in AD than that in AA (P<.05). The longitudinal TS of AD obtained excellent negative correlations with blood and tissue homogenized levels of IL-6 and TNF-α (P<.05), while there was no significant correlation between the parameters of AA.
Conclusion
AD patients had obviously acute systemic inflammation, along with acute inflammation and declined biomechanical strength of affected aorta. The blood and tissue homogenized levels of IL-6 and TNF-α in AD got excellent correlations with the biomechanical strength of affected aorta.

Keywords: aortic dissection, inflammation, tensile strength, interleukin-6, tumor necrosis factor-α,




Corresponding Author: Wei Meng, China


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