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Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(3): 213-221 | DOI: 10.14744/AnatolJCardiol.2018.53059  

Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model

Anzel Bahadır1, Ayşe Ceyhan2, Özlem Öz Gergin3, Betül Yalçın2, Menekse Ülger2, Tuğçe Merve Özyazgan2, Arzu Yay2
1Department of Biophysics, Faculty of Medicine, Düzce University; Düzce-Turkey
2Department of Histology and Embryology, Faculty of Medicine, Erciyes University; Kayseri-Turkey
3Department of Anesthesiology and Reanimation, Kayseri Training and Research Hospital; Kayseri-Turkey

Objective: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues.
Methods: A total of 49 adult female Wistar albino rats were equally divided into seven groups as follows: control (no medication), sesame oil (1 mg/kg), CDDP (single dose injection two times as once a week, 5 mg/kg/week), BC (100 mg/kg), CDDP+BC (pretreated BC for 30 min before CDDP injection), CMN (200 mg/kg), and CDDP+CMN (pretreated CMN for 30 min before CDDP injection). These treatments were applied intraperitoneally for CDDP and with gavage for CMN and BC. The oxidative/antioxidant indicators, inflammatory cytokines, and histopathological alterations were examined.
Results: These alterations included a marked increase in malondialdehyde (MDA) level, significant decrease in catalase (CAT) and superoxide dismutase (SOD) activities, and significant elevation of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interleukin (IL)-6 in the CDDP group compared with the other groups. Histopathologically, CDDP-induced severe myocardial degenerative changes were observed. However, the CDDP-induced disturbances in the above-mentioned parameters significantly improved by treatment with BC and particularly CMN.
Conclusion: This study indicated that CDDP treatment markedly caused cardiotoxicity; however, treatment with CMN or BC ameliorated this cardiotoxicity in rats. Furthermore, these findings revealed that treatment with CMN has a higher cardioprotective effect than that with BC against CDDP-induced cardiotoxicity in rat cardiac tissues.

Keywords: cisplatin, cardiotoxicity, curcumin, beta-carotene, rat heart tissue


Anzel Bahadır, Ayşe Ceyhan, Özlem Öz Gergin, Betül Yalçın, Menekse Ülger, Tuğçe Merve Özyazgan, Arzu Yay. Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model. Anatol J Cardiol. 2018; 19(3): 213-221

Corresponding Author: Anzel Bahadır, Türkiye


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