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Effect of weight loss on QTc dispersion in obese subjects [Anatol J Cardiol]
Anatol J Cardiol. 2006; 6(2): 126-129

Effect of weight loss on QTc dispersion in obese subjects

Ergun Seyfeli1, Mehmet Duru2, Güven Kuvandik2, Hasan Kaya3, Fatih Yalçın4
1From Department of Cardiology School of Medicine, Mustafa Kemal University, Hatay, Turkey
2From Department of Emergency Medicine School of Medicine, Mustafa Kemal University, Hatay, Turkey
3Department of Cardiology, Faculty of Medicine, Dicle University, Diyarbakır-Turkey
4Department of Cardiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey

Objective: Increased QTc dispersion is a predictor for ventricular arrhythmias. The aim of this study was to investigate whether QTc dis- persion decreases after weight loss program with diet and medical treatment. Methods: Total 30 (24 women and 6 men, mean age: 44±8 years) obese subjects who lost at least 10% of their original weight after 12 week weight loss program were included in present study. Obesity was defined as ≥30 kg/m2 of body mass index (BMI). Normal weight was defined as ≤ 25 kg/m2 of BMI. Results: After 12 week weight loss program, BMI decreased from 42±5 kg/m2 to 36±4 kg/m2 (p<0.001) and mean weight of obese subjects decreased from 110±17 kg to 95±15 kg (p<0.001). The mean amount of weight loss was 14.5±5.0 kg (range 9-32 kg). The average percent of weight loss was 13% (10.0%-20.3%). Maximum QTc interval (from 446±19 ms to 433±27 ms, p=0.024) and QTc dispersion (from 66±18 ms to 52±25 ms, p=0.024) significantly decreased after weight loss program. A statistically significant correlation was found between decrease in level of QTc dispersion and amount of weight loss (r=0.487, p=0.007). Conclusion: Substantial weight loss in obese subjects is accompanied by significantly decreased QTc dispersion. The degree of QTc dis- persion reduction is associated with amount of weight loss.

Keywords: Obesity, weight loss, electrocardiographic marker, QTc dispersion


Ergun Seyfeli, Mehmet Duru, Güven Kuvandik, Hasan Kaya, Fatih Yalçın. Effect of weight loss on QTc dispersion in obese subjects. Anatol J Cardiol. 2006; 6(2): 126-129


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