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Effects of treadmill exercise test on oxidative/antioxidative parameters and DNA damage [Anatol J Cardiol]
Anatol J Cardiol. 2006; 6(2): 135-140

Effects of treadmill exercise test on oxidative/antioxidative parameters and DNA damage

Recep Demirbağ1, Remzi Yılmaz2, Salih Güzel3, Hakim Çelik3, Abdurrahim Koçyiğit3, Erel Özcan3
1Department of Cardiology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey
2Harran Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Şanlıurfa, Türkiye
3From Department of Clinical Chemistry Faculty of Medicine, Harran University, Şanlıurfa, Turkey

Objective: We investigated the acute effects of treadmill exercise test (TET) on total peroxide, total antioxidant capacity (TAC), oxidative stress index (OSI) and DNA damage levels in voluntary and untrained healthy subjects. Methods: A total of 113 untrained healthy subjects were included in the study. All subjects maintained a similar diet and physical activi- ty for a week before the test. Blood samples were obtained before and after TET. Total peroxide, TAC, vitamin C and DNA damage were measured. The DNA damage was analyzed by using the Comet assay and OSI was calculated using total peroxide and TAC values. Results: Treadmill exercise test leads to the increase of total peroxide (12 ± 3 μmol H2O2/L to 14 ± 3 μmol H2O2/L, p<0.001), OSI (0.72 ± 0.18 AU to 0.81 ± 0.22 AU, p<0.001), and to the decrease of TAC (1.78 ± 0.16 mmol Trolox Eq./L to 1.72 ± 0.15 mmol Trolox Eq./L, p<0.001) and vit- amin C levels (98 ± 4.2 μmol/L to 95 ± 3.4 μmol/L, p<0.001). There was not significant difference in DNA damage. Conclusion: Our findings demonstrate that TET increases oxidants, decreases TAC and vitamin C namely, the balance shift towards oxida- tive side, but this stress is not enough to produce DNA damage.

Keywords: Antioxidants, treadmill exercise test, DNA damage, oxidants


Recep Demirbağ, Remzi Yılmaz, Salih Güzel, Hakim Çelik, Abdurrahim Koçyiğit, Erel Özcan. Effects of treadmill exercise test on oxidative/antioxidative parameters and DNA damage. Anatol J Cardiol. 2006; 6(2): 135-140


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