ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 18 Issue : 4 Year: 2017
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Major bleeding events in Jordanian patients undergoing percutaneous coronary intervention (PCI): Incidence, associated factors, impact on prognosis, and predictability of the CRUSADE bleeding risk score. Results from the First Jordanian PCR (PCR1) [Anatol J Cardiol]
Anatol J Cardiol. 2017; 17(6): 445-451 | DOI: 10.14744/AnatolJCardiol.2017.7530  

Major bleeding events in Jordanian patients undergoing percutaneous coronary intervention (PCI): Incidence, associated factors, impact on prognosis, and predictability of the CRUSADE bleeding risk score. Results from the First Jordanian PCR (PCR1)

Mohamad Jarrah1, Ayman Hammoudeh2, Osama Okkeh2, Yousef Khader3, Sahem Gharaibeh1, Laith Nasser1, Amro Rasheed4, Ayed Al-hindi4, Mohammad Mohealdeen4, Haneen Kharabsheh1, Hanan Abunimeh5, Enas Hijjih5, Lina Tashman5, Delia Omar5, Nadeen Kufoof6
1Division of Cardiology, Internal Medicine Department, King Abdullah University Hospital, Jordan University of Science and Technology; Irbid-Jordan
2Interventional Cardiology Service, Istishari Hospital; Amman-Jordan
3Faculty of Medicine, Jordan University of Science and Technology; Irbid-Jordan
4Department of Cardiology, Islamic Hospital; Amman-Jordan
5Pharmaceutical Services Department, Ibn Haitham Hospital; Amman-Jordan
6Pharmaceutical Services Department, Arab Medical Center; Amman-Jordan

Objective: Determine the incidence of major bleeding events, their risk factors, and their impact on prognosis in Jordanian patients undergoing percutaneous coronary intervention (PCI). Evaluate the ability of the CRUSADE bleeding risk score (BRS) to predict major bleeding. Methods: Major bleeding events were defined according to the CRUSADE classification and their incidence was evaluated from hospital admission to one year of follow up. The CRUSADE bleeding risk score was calculated for each patient during the index admission. Incidence of major bleeding events was evaluated in each of the bleeding score quintiles. JoPCR1 is a prospective, observational, multicenter registry of consecutive patients who underwent PCI at 12 tertiary care centers in Jordan. A case report form was used to record data prospectively at hospital admission, at discharge, and at 1 and 12 months of follow-up. Results: The study included 2426 consecutive patients who underwent PCI. During the index hospitalization, major and minor bleeding events occurred in 0.95% and 2.6% of patients, respectively. Multivariate analysis showed that only two variables were significantly associated with major bleeding: female gender (OR=3.7; 95% CI 1.6, 8.5; p=0.002) and past history of cardiovascular disease (OR=2.6; 95% CI 1.1, 5.9; p=0.026). Patients who had in-hospital major bleeding events had higher cardiac mortality during index hospitalization (13.0% vs. 0.7%, p<0.005) and at one year of follow up (13.0% vs. 1.8%, p<0.005) compared to those who had no such events. Receiver operating characteristic curve analysis showed that the CRUSADE BRS has a high ability to predict major bleeding. Conclusion: Major bleeding events were uncommon in this ME registry of a contemporary cohort of patients undergoing PCI but were associated with a higher mortality rate compared with those who did not have major bleeding events. CRUSADE BRS was highly predictive of the incidence of major bleeding events.

Keywords: major bleeding events, percutaneous coronary intervention, CRUSADE bleeding risk score


Mohamad Jarrah, Ayman Hammoudeh, Osama Okkeh, Yousef Khader, Sahem Gharaibeh, Laith Nasser, Amro Rasheed, Ayed Al-hindi, Mohammad Mohealdeen, Haneen Kharabsheh, Hanan Abunimeh, Enas Hijjih, Lina Tashman, Delia Omar, Nadeen Kufoof. Major bleeding events in Jordanian patients undergoing percutaneous coronary intervention (PCI): Incidence, associated factors, impact on prognosis, and predictability of the CRUSADE bleeding risk score. Results from the First Jordanian PCR (PCR1). Anatol J Cardiol. 2017; 17(6): 445-451

Corresponding Author: Mohamad Jarrah, Jordan


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright 2016 Turkish Society of Cardiology