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The value of real-time myocardial contrast echocardiography for detecting coronary microcirculation function in coronary artery disease patients [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(1): 27-33 | DOI: 10.14744/AnatolJCardiol.2017.8041  

The value of real-time myocardial contrast echocardiography for detecting coronary microcirculation function in coronary artery disease patients

Lulu Sun1, Zilong Wang3, Tongda Xu2, Defeng Pan2, Li Liang1, Ji Hao1, Xiaoping Wang2, Dongye Li1
1Institute of Cardiovascular Disease Research, Xuzhou Medical University, Jiangsu Province-P. R. China
2Department of Cardiology of Affiliated Hospital of Xuzhou Medical University, Jiangsu Province-P. R. China
3Department of Cardiology of Affiliated Zhongshan Hospital of Fudan University, Qingpu Branch, Shanghai Municipality-P. R. China

Objective: The aim of this study was to evaluate the value of real-time myocardial contrast echocardiography (RT-MCE) for detecting coronary microcirculation (CM) function in coronary artery disease (CAD) patients.
Methods: Sixty-five consecutive patients were divided into CAD (n=52) and no-CAD (n=13) groups using coronary angiography (CAG). All patients underwent RT-MCE at rest and CAG within 1 week after RT-MCE. The ventricular segments in CAD patients were divided semi-quantitatively into ischemic and non-ischemic myocardial groups based on RT-MCE images. Myocardial blood volume (A), myocardial blood flow velocity (β), and mean myocardial blood flow (Aβ) were obtained. The Gensini scores were calculated for CAD patients. The receiver operating characteristic (ROC) curve areas of A, β, and Aβ were calculated to assess CM function in CAD patients.
Results: A total of 798 and 204 segments were investigated in the CAD and non-CAD groups, respectively. In CAD patients, 332 ischemic and 466 non-ischemic segments were identified. The values of A, β, and Aβ were significantly different among non-CAD, CAD, ischemic, and non-ischemic groups. ROC curve areas of A, β, and Aβ were 0.85, 0.79, and 0.83, respectively, and significant differences were observed in these values among three Gensini score groups of the CAD patients.
Conclusion: Varying degrees of CM function deterioration was observed in CAD patients both in ischemic and non-ischemic areas, with the deterioration being more sever in the former.

Keywords: real-time myocardial contrast echocardiography, coronary angiography, coronary microcirculation function


Lulu Sun, Zilong Wang, Tongda Xu, Defeng Pan, Li Liang, Ji Hao, Xiaoping Wang, Dongye Li. The value of real-time myocardial contrast echocardiography for detecting coronary microcirculation function in coronary artery disease patients. Anatol J Cardiol. 2018; 19(1): 27-33

Corresponding Author: Dongye Li, China


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