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Relation of diabetes to coronary artery ectasia: A meta-analysis study [Anatol J Cardiol]
Anatol J Cardiol. 2014; 14(4): 322-327 | DOI: 10.5152/akd.2014.5327  

Relation of diabetes to coronary artery ectasia: A meta-analysis study

Qiao-Juan Huang1, Jun Liu1, Meng-Hua Chen3, Jian-Jun Li1
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China
2Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China
3Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University; Nanning, Guangxi-PR China
4Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China

Objective: Previous studies have shown a significant negative association between diabetes and abdominal aortic aneurysm. However, the relation of diabetes to coronary artery ectasia (CAE) has not well established. The aim of the current study was to conduct a systemic review for evaluating the relationship between diabetes and CAE. Methods: A systemic search of electronic databases (PUBMED, EMBASE, OVID, WEB OF SCIENCE, THE COCHRANCE LIBRARY) from 1970 to March 2013 was performed. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific meetings were also carried out. All case-control studies investigating appropriate prevalence data were included. Results: Among 328 articles, 10 case-control studies were finally identified. The prevalence of diabetes in studied patients with CAE was 8% to 33%, while in those without CAE was ranged from 13.5% to 35%. Pooled analysis showed a reduced rate of diabetes amongst patients with CAE compared to those without (OR 0.65, 0.54-0.77, p<0.0001). Conclusion: Our findings suggested that diabetes might play a protective role for the development of CAE, indicating that further study is needed to evaluate the association diabetes and CAE including underlying mechanisms and future medical interventional strategies.

Keywords: coronary artery ectasia, diabetes, meta-analysis


Diyabetin koroner arter ektazi ile ilişkisi: Bir meta-analiz çalışması

Qiao-Juan Huang1, Jun Liu1, Meng-Hua Chen3, Jian-Jun Li1
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China
2Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China
3Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University; Nanning, Guangxi-PR China
4Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College; Beijing-China

Amaç: Önceki çalışmalar diyabet ile abdominal aort anevrizması arasında anlamlı negatif bir ilişki olduğunu göstermiştir. Ancak, diyabet ve koroner arter ektazisi (KAE) arasındaki tam bir ilişki kurulamamıştır. Bu çalışmanın amacı, diyabet ve KAE arasındaki ilişkiyi değerlendirmek için sistemik bir inceleme yapmaktır. Yöntemler: 1970-2013 Mart tarihleri arasında elektronik veri tabanlarında (PUBMED, EMBASE, OVID, WEB OF SCIENCE, THE COCHRANCE LIBRARY) sistemik bir araştırma yapıldı. Ayrıca, belirlenen makaleler, derlemeler ve ilgili bilimsel toplantılarda sunulan özetlerin referans listeleri de kontrol edilerek, yapıldı. Tüm olgu-kontrol çalışmaları araştırılarak uygun prevalans verileri dahil edildi. Bulgular: Üç yüz yirmi sekiz makale arasında, sonunda 10 vaka-kontrollü çalışma belirlendi. KAE olan çalışma hastalarında diyabet prevalansı %8-%33, buna karşılık KAE olmayanlarda ise bu oran %13,5-%35 arasında değişmektedir. Toplu analiz, KAE olanlar, olmayan hastalarla karşılaştırıldığında diyabet oranının düştüğü gösterildi (OR 0.65, 0.54-0.77, p<0,0001). Sonuç: Bulgularımız, diyabetin KAE gelişimi için koruyucu bir rol oynadığını, gelecekteki tıbbi girişimsel stratejileri ve altında yatan mekanizmaları içeren; diyabet ve KAE ilişkisini değerlendiren daha ileri çalışmalara ihtiyaç olduğunu göstermiştir.

Anahtar Kelimeler: koroner arter ektazisi, diyabet, meta-analiz


Qiao-Juan Huang, Jun Liu, Meng-Hua Chen, Jian-Jun Li. Relation of diabetes to coronary artery ectasia: A meta-analysis study. Anatol J Cardiol. 2014; 14(4): 322-327


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