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A comparison of the in vivo neoendothelialization and wound healing processes of three atrial septal defect occluders used during childhood in a nonrandomized prospective trial [Anatol J Cardiol]
Anatol J Cardiol. 2017; 18(3): 229-234 | DOI: 10.14744/AnatolJCardiol.2017.7540  

A comparison of the in vivo neoendothelialization and wound healing processes of three atrial septal defect occluders used during childhood in a nonrandomized prospective trial

Derya Aydın Şahin1, Osman Başpınar1, Ayşe Sülü1, Tekin Karslıgil2, Seval Kul3
1Department of Pediatric Cardiology, Medical Faculty of Gaziantep University; Gaziantep-Turkey
2Department of Microbiology, Medical Faculty of Gaziantep University; Gaziantep-Turkey
3Department of Biostatistics, Medical Faculty of Gaziantep University; Gaziantep-Turkey

Objective: We prospectively investigated the neoendothelialization of transcatheter secundum atrial septal defect (ASD) closure in children receiving one of three different occluders.
Methods: Transcatheter ASD closure was performed for 44 children. The patients were divided into three groups: group I: Amplatzer, group II: Lifetech CeraFlex, and group III: Occlutech Figulla Flex II septal occluder. The data were prospectively analyzed. Markers of the three phases of wound healing were studied in all patients before and on the 1st and 10th days and 1st month post intervention.
Results: The mean age of children was 7.08±3.51 years, and the mean weight was 26.07±15.07 kg. The mean ASD diameter was 12.65±3.50 mm. Groups I, II, and III comprised 34.1%, 31.8%, and 34.1% patients, respectively. No significant differences were observed between the groups regarding patient number, age, defect size, device diameter, or total septum/device ratio (p>0.05). Inflammatory and proliferative phase marker levels increased following the procedure (p<0.05). However, scar formation markers did not change after 1 month. No significant differences in neoendothelializaton were observed among the different occluders (p>0.05).
Conclusion: All three devices were composed of nitinol with different surface coating techniques. Although the different manufacturing features were claimed to facilitate of neoendothelialization, no differences were observed among the three devices 1 month following the procedure.

Keywords: secundum atrial septal defect, transcatheter closure, septal occluders, neoendothelialization, children


Derya Aydın Şahin, Osman Başpınar, Ayşe Sülü, Tekin Karslıgil, Seval Kul. A comparison of the in vivo neoendothelialization and wound healing processes of three atrial septal defect occluders used during childhood in a nonrandomized prospective trial. Anatol J Cardiol. 2017; 18(3): 229-234

Corresponding Author: Derya Aydın Şahin, Türkiye


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