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MACE and Drug Coated Balloon Size in Coronary Interventions [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-67864 | DOI: 10.14744/AnatolJCardiol.2018.67864  

MACE and Drug Coated Balloon Size in Coronary Interventions

David Naguib, Betül Knoop, Lisa Dannenberg, Eva Liebsch, Martin Pöhl, Carolin Helten, Athena Assadi-schmidt, Malte Kelm, Tobias Zeus, Amin Polzin
Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany

Objectives: In-stent restenosis (ISR) is a feared complication after coronary stent implantation. Drug coating balloon (DCB) is a promotion option in treatment of ISR. However, the benefit-risk ratio of DCB length has not been investigated. Longer DCB release more antiproliferative drug to the vessel wall, on the other hand are associated with higher lesion length and vessel injury.
Hypothesis: DCB length is associated with clinical outcome.
Methods: We analyzed 286 consecutive Pantera Lux (Biotronik, active component Paclitaxel) DCB treated patients between April 2009 and June 2012. Of these patients, 176 were treated with a 15mm DCB and 109 patients with a 20mm DCB. Baseline characteristics and MACE (death, myocardial infarction and target lesion revascularization) during initial hospital stay and a two year follow up period were obtained.
Results: Patients characteristics such as cardiovascular risk factors, prior diseases, co-medication, clinical presentation, target vessel and left ventricular function did not differ between groups. MACE during hospital course was similar (1.7% vs. 2.8%, relative risk [RR] 1.6, 95% confidence interval [CI] 0.3-7.9, p= 0.554). Likewise, at two-year follow up MACE did not differ between patients (23.2% vs. 27.5%, RR 1.2, 95% CI 0.6-1.5, p= 0.408).
Conclusion: DCB length was not associated with clinical outcome during a two-year follow-up period.

Keywords: Drug coated balloon, drug eluting balloon, length, MACE, paclitaxel

Corresponding Author: Lisa Dannenberg, Germany

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