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Association of Interleukin-1 Gene cluster polymorphisms with coronary slow flow phenomenon [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(1): 34-41 | DOI: 10.14744/AnatolJCardiol.2017.8071  

Association of Interleukin-1 Gene cluster polymorphisms with coronary slow flow phenomenon

Ferit Onur Mutluer1, Dilek Ural1, Barış Güngör2, Osman Bolca2, Tolga Aksu3
1Department of Cardiology, Koç University Hospital, İstanbul-Turkey
2Department of Cardiology, Siyami Ersek Training and Research Hospital, İstanbul-Turkey
3Department of Cardiology, Kocaeli Derince Trainig and Research Hospital, Kocaeli-Turkey

Objective: Coronary slow flow phenomenon (CSFP) is characterized by the decreased rate of contrast progression in epicardial coronary arte-ries in the absence of significant coronary stenosis. Mounting evidence has showed a significant association between inflammation and CSFP severity. This study aimed to evaluate possible associations between interleukin-1 receptor antagonist (IL-1ra) gene variable number tandem repeat (VNTR), IL-1β -511 single nucleotide (SNP), and IL-1β+3954 SNP mutations with CSFP.
Methods: Forty-eight patients with CSFP and 62 controls with angiographically normal coronary arteries were prospectively enrolled in the study. Genotypes were assessed using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism (PCR-RFLP) technique.
Results: Homozygote genotype for allele 2 of+3954 C>T 2/2 genotype was significantly more frequent in patients with CSFP than in the control group, whereas 1/2 genotype was more frequent in the control group (35.4% versus 14.5% for 2/2 genotype and 25% versus 35.5% for 1/2 genotype in CSFP and control groups, respectively, X2=6.6; p=0.04). The allelic frequency of allele 2 of this polymorphism was significantly higher in the CSFP group than in the control group (47.9% versus 28.6% in the control group, X2=5.6; p=0.02). However, there was no significant difference with regard to genotype or allelic frequencies of IL-1ra VNTR or IL-1β -511 SNP polymorphisms between patients with CSFP and controls.
Conclusion: IL-1β+3954 SNP mutations are significantly more common in patients with CSFP. It may suggest that the tendency for inflammation may contribute to the presence of this phenomenon.

Keywords: atherosclerosis, interleukins, oxidative stress, endothelium, vascular smooth muscle

Ferit Onur Mutluer, Dilek Ural, Barış Güngör, Osman Bolca, Tolga Aksu. Association of Interleukin-1 Gene cluster polymorphisms with coronary slow flow phenomenon. Anatol J Cardiol. 2018; 19(1): 34-41

Corresponding Author: Tolga Aksu

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