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Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2012; 12(4): 298-304 | DOI: 10.5152/akd.2012.092  

Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study

Adem Parlak1, Ümit Aydoğan1, Atila İyisoy2, Mehmet Aytuğ Dikililer5, Altuğ Kut6, Erdinç Çakır3, Kenan Sağlam4
1From Departments of Family Medicine, Gülhane Military Medical Academy, Ankara
2Cardiology, Gülhane Military Medical Academy, Ankara
3Medical Biochemistry, Gülhane Military Medical Academy, Ankara
4Internal Medicine, Gülhane Military Medical Academy, Ankara
5Department of Family Medicine, Şırnak Military Hospital, Şırnak
6Department of Family Medicine, Başkent Hospital, Ankara-Turkey

Objective: In this study, relationship between systolic and diastolic blood pressure and pentraxin-3 (PTX3) levels in hypertensive patients was investigated.
Methods: Overall, 80 patients with stage 1 hypertension between 40-61 years of age without any disease and 80 healthy volunteers were included to the study. Blood samples obtained to measure PTX3 levels and biochemical analysis. Relationship between PTX3 levels and clinical and biochemical parameters were analyzed using multivariate regression analysis.
Results: Although systolic and diastolic blood pressures were significant different, there were no differences regarding age and gender between hypertensives and normotensives. In each group, significant statistical differences were found between PTX3 and CRP levels (PTX3 (ng/mL) 35.25±5.45 and 0.27±0.24, p<0.001; CRP (mg/dL) 10.03±5.81 and 4.30±3.38, p<0.001; in hypertensive and normotensive groups respectively). It was observed that increase in PTX3 levels accompanies the increase in systolic and diastolic blood pressures (r2=0.78). It was observed that PTX3 levels are not effected from CRP, lipid levels and body mass index (p>0.05). On multivariate regression analysis PTX3 was found to strongly affect blood pressure (beta=0.82, 95% CI 0.644-0.799, p<0.001, and beta=0.84, 95% CI 0.422-0.799, p<0.001, respectively for systolic and diastolic blood pressures), CRP and total cholesterol are found to affect moderately (beta=0.115-0.265, 95% CI 0.101-0.572, p<0.05 and beta=0.107-0.141, 95% CI 0.041-0.110, p<0.05, respectively).
Conclusion: This study showed that PTX3 levels are higher in newly diagnosed hypertensive patients than in healthy individuals. In addition, it was noticed that increased PTX3 levels causes increase in systolic and diastolic blood pressures. (Anadolu Kardiyol Derg 2012; 12: 298-304)

Keywords: Hypertension, pentraxin3, inflammatory mediators, regression analysis


Adem Parlak, Ümit Aydoğan, Atila İyisoy, Mehmet Aytuğ Dikililer, Altuğ Kut, Erdinç Çakır, Kenan Sağlam. Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study. Anatol J Cardiol. 2012; 12(4): 298-304

Corresponding Author: Adem Parlak, Türkiye


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