ISSN 2149-2263 | E-ISSN 2149-2271
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Comparison of the Antioxidant Enzyme Levels with the Degree of Dysfunction in Patients with Myocardial Dysfunction [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(2): 130-134

Comparison of the Antioxidant Enzyme Levels with the Degree of Dysfunction in Patients with Myocardial Dysfunction

Nurşen Sezgin1, Alpay Tufan Sezgin2, Aysun Karabulut1, Ergün Topal3, İrfan Barutçu3, M. Gözükara3
1İnönü Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Malatya
2Department of Cardiology, Başkent University School of Medicine, Ankara, Turkey
3İnönü Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Malatya

Objective: Myocardial dysfunction in patients with cardiomyopathy is proposed to occur due to membrane changes caused by oxidative stress. In our study we evaluate whether there is any relation between the degree of myocardial dysfunction and antioxidant enzymes. Methods: We studied superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) enzyme activities from blood samples of 60 patients (30 patients had ejection fraction (EF) <%35 and 30 patients had EF= %35-50) who have myocardial dysfunction according to clinical findings and two-dimensional echocardiography, and 20 healthy volunteers. Results: We found erythrocyte SOD enzyme activities of patients with EF <%35 (group 3) were significantly lower than in control subjects (group 1) (p=0.01). However in group 2 patients (EF= %35-50), erythrocyte SOD activities were found to be lower than in control subjects but this difference was not significant. Erythrocyte CAT and GSHPx enzyme activities of group 3 were also significantly lower than in control group (p=0.04 and p=0.02 respectively). Conclusion: In conclusion, reactive oxygen species play a significant role in the initiation and the progression of congestive heart failure. Increased free radicals levels may cause myocardial muscle dysfunction.

Keywords: Free oxygen radicals, antioxidant enzyme, ischemic cardiomyopathy

Miyokard Disfonksiyonu Olan Hastalarda Disfonksiyonun Derecesi ile Antioksidan Enzim Düzeylerinin Karşılaştırılması

Nurşen Sezgin1, Alpay Tufan Sezgin2, Aysun Karabulut1, Ergün Topal3, İrfan Barutçu3, M. Gözükara3
1İnönü Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Malatya
2Department of Cardiology, Başkent University School of Medicine, Ankara, Turkey
3İnönü Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Malatya

Anahtar Kelimeler: Serbest oksijen radikalleri, antioksidan enzim, iskemik kardiyomiyopati

Nurşen Sezgin, Alpay Tufan Sezgin, Aysun Karabulut, Ergün Topal, İrfan Barutçu, M. Gözükara. Comparison of the Antioxidant Enzyme Levels with the Degree of Dysfunction in Patients with Myocardial Dysfunction. Anatol J Cardiol. 2004; 4(2): 130-134
Manuscript Language: English


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