EDITORIAL | |
1. | Periodical publishing policy of the science world Bilgin Timuralp PMID: 28529285 PMCID: PMC5469079 doi: 10.14744/AnatolJCardiol.2017.05 Pages 349 - 350 Abstract |Full Text PDF |
INVITED REVIEW | |
2. | Highlights from ACC.17 scientific sessions Mehmet Birhan Yılmaz, Mahmut Şahin PMID: 28529286 PMCID: PMC5469080 doi: 10.14744/AnatolJCardiol.2017.7903 Pages 351 - 352 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
3. | New oral anticoagulants-TURKey (NOAC-TURK): Multicenter cross-sectional study Servet Altay, Özlem Yıldırımtürk, Hüseyin Altuğ Çakmak, Lütfü Aşkın, Ümit Yaşar Sinan, Feyzullah Beşli, Ömer Gedikli, Özge Özden Tok PMID: 28100898 PMCID: PMC5469081 doi: 10.14744/AnatolJCardiol.2016.7472 Pages 353 - 361 Objective: New oral anticoagulants (NOACs) are increasingly used both for prevention of stroke in non-valvular atrial fibrillation (NVAF) and the treatment of venous thromboembolism (VTE). In this study, we aimed to evaluate the current patterns of NOACs treatment in Turkey. Moreover, demographic and clinical parameters and bleeding and/or embolic events under NOACs treatment were analyzed. Methods: The New Oral Anticoagulants-TURKey (NOAC-TURK) study was designed as a multicenter cross-sectional study. A total of 2,862 patients from 21 different centers of Turkey under the treatment of NOACs for at least three months were included in this study. Demographic, clinical, and laboratory characteristics of study participants with their medications used were obtained through the NOAC-TURK survey database. Additional necessary medical records were obtained from electronic health records of participating centers. Results: Of the 2. 862 patients, 1.131 (39.5%) were male and the mean age was 70.3±10.2 years. Hypertension was found as the most frequent comorbidity (81%). The most common indication for NOACs was permanent atrial fibrillation (83.3%). NOACs were mainly preferred because of inadequate therapeutic range or overdose during warfarin usage. The most frequent complication was bleeding (n=217, 7.6%), and major bleeding was observed in 1.1% of the patients. Embolic events were observed in 37 patients (1.3%). Rivaroxaban and dabigatran were both more preferred than apixaban. Almost half of the patients (47.6%) were using lower doses of NOACs, which is definitely much more than expected. Conclusion: The NOAC-TURK study showed an important overview of the current NOACs treatment regimens in Turkey. Although embolic and bleeding complications were lower than or similar to previous studies, increased utilization of low-dose NOACs in this study should be considered carefully. According to the results of this study, NOACs treatment should be guided through CHA2DS2-VASc and HASBLED scores to ensure more benefit and less adverse effects in NVAF patients. |
4. | Role of simvastatin and RORα activity in the macrophage apoptotic pathway Neslihan Çoban, Çağrı Güleç, Bilge Özsait Selçuk, Nihan Erginel Ünaltuna PMID: 28179616 PMCID: PMC5469082 doi: 10.14744/AnatolJCardiol.2016.7411 Pages 362 - 366 Objective: Atherosclerosis is a chronic inflammatory condition and is one of the main causes of death worldwide. Macrophages play important roles in the formation of atherosclerotic plaques. Apoptosis is progressively observed while plaques develop, although the precise mechanisms and outcomes of apoptosis in atherosclerosis development and progression are still contradictory. This study was conducted to explore the ef- fects of simvastatin and retinoic acid receptor-related orphan receptor alpha (RORα) ligands on apoptosis in human acute monocytic leukemia (THP-1) macrophage cells. Methods: Briefly, the occupancy of RORα in the promoter regions of apoptotic pathway genes was demonstrated in THP-1 cell lines using chromatin immunoprecipitation (ChIP) analysis. In order to modulate RORα activity, THP-1 macrophage cells were treated with specific ligands (CPG52608 and SR1001) and then viability as well as count of THP-1 macrophage cells were analyzed. Results: We observed that simvastatin and both RORα ligands had a tendency to decrease THP-1 macrophage cell viability in culture. When compared with non-treated controls, simvastatin significantly decreased cell viability (p=0.04) and cell count (p=0.03). However, this negative effect of simvastatin seemed to be partly prevented by RORα ligands. In addition, bioinformatics analysis of ChIP-on-chip data demonstrated that several genes that are involved in the apoptotic pathway were likely RORα target genes. These genes were involved in the regulation of apoptosis through various pathways. Conclusion: In summary, our study suggest that simvastatin-mediated macrophage apoptosis might be modulated by SR1001 administration. However, involvement of RORα in this modulation through potential apoptotic target genes remains elusive. (Anatol J Cardiol 2017; 17: 000-00) |
5. | X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-β1/Smad3 and p38 MAPK pathway Yunliang Wei, Changsheng Guo, Jingsheng Zhao, Jun Yang, Weiguo Yi, Hong Liu, Xinwei Lin, Zhengchen Zhang PMID: 28100897 PMCID: PMC5469083 doi: 10.14744/AnatolJCardiol.2016.7438 Pages 367 - 373 Objective: Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved. Methods: Transverse aortic constriction (TAC) was conducted to induce a CHF rat model in this study. Sixty male Wistar rats were randomly assigned to six groups 28 days after TAC: sham; CHF model; Xin at concentrations of 5 ml/kg, 10 mL/kg, and 20 mL/kg; and QiLi 0.6 g/kg. After four weeks, the rats were treated with Xin (5, 10, or 20 mL/kg/d) for six weeks consecutively. At the end of the study, the cardiac function, heart weight index (HWI) and left ventricular mass index (LVMI), serum level of LDH, B-type natriuretic peptide (BNP), cTnI and CK-MB, and collagen volume fraction were studied. The expression of transforming growth factor-β1 (TGF-β1), drosophila mothers against decapentaplegic protein 3 (Smad3), and p38 mitogen activated protein kinase (p38 MAPK) were detected. Results: The results showed that Xin treatment significantly improved cardiac function but decreased the serum level of LDH, BNP, cTnI, and CKMB of CHF rats. In addition, it reduced the HWI, LVMI, and collagen volume fraction compared with the model group. Xin treatment significantly improved cardiac function and attenuated cardiac fibrosis by suppressing the p38 MAPK and TGF-β1/Smad3 signaling pathway in CHF rats. Conclusion: These results suggested that Xin might be a promising complementary treatment for CHF. More detailed experimental studies will be carried out in our subsequent research. |
6. | Assessment of atrial conduction times in prediabetic patients with coronary artery disease Mahdokht Rezaei, Ali Hosseinsabet PMID: 27965511 PMCID: PMC5469084 doi: 10.14744/AnatolJCardiol.2016.7396 Pages 374 - 380 Objective: Prediabetes is a dysglycemic state and is associated with subtle myocardial injury and dysfunction. We evaluated atrial conduction times (ACTs) and atrial electromechanical delays (EMDs) in prediabetic patients with coronary artery disease (CAD). Methods: In the present study, we recruited 128 consecutive patient candidates (40 euglycemic, 48 prediabetic, and 40 diabetic patients) for coronary artery bypass grafting. ACTs were measured using tissue Doppler imaging (TDI). The time intervals between the beginning of the P wave in the surface electrocardiogram and the peak of the a′ wave in TDI (PA) in the septal and lateral mitral annuli and the lateral tricuspid annulus were measured and termed as "septal PA," "lateral PA," and "right ventricular (RV) PA," respectively. The differences between lateral and septal PA, septal and RV PA, and lateral and RV PA were termed as "left intra-atrial EMD," "right intra-atrial EMD," and "inter-atrial EMD" respectively. Results: Septal PA, lateral PA, RV PA, left and right intra-atrial EMDs, and inter-atrial EMD were not statistically different between these three groups. Furthermore, multivariable linear regression models, adjusted for potential confounders, showed that glycemic state was not associated with ACTs, left and right intra-atrial EMDs, and inter-atrial EMD. Conclusion: There were no significant differences between the euglycemic, prediabetic, and diabetic patients with CAD regarding ACTs and atrial EMDs. |
7. | Baseline serum globulin as a predictor of the recurrence of lone atrial fibrillation after radiofrequency catheter ablation Qing Zhou, Hailong Cao, Zhenjun Xu, Rongfang Lan, Xin Chen, Dongjin Wang, Wei Xu PMID: 28613212 PMCID: PMC5469085 doi: 10.14744/AnatolJCardiol.2016.7393 Pages 381 - 385 Objective: Inflammation and autoimmune responses play an important role in recurrence of atrial fibrillation (AF). Serum globulin levels are a commonly used clinical index that represents inflammation and autoimmune response. This study aimed to determine the relationship between baseline serum globulin levels and the risk of recurrence after ablation in lone AF patients. Methods: We enrolled 348 lone AF patients undergoing radiofrequency catheter ablation for the first time for whom complete follow-up data were available. Pre-ablation peripheral venous blood samples were obtained for measurement of serum globulin levels. Results: During the follow-up period of 22 months (range, 6–62), AF recurred in 129 patients (37.1%). Recurrence was associated with a low level of pre-ablation serum globulins. Multiple Cox proportional hazard regression analysis showed that persistent AF, AF duration, left atrial diameter, no amiodarone after ablation, and the serum globulin level in particular were independent predictors of AF recurrence. According to receiver operating characteristic curve analysis, the best diagnostic cut-off serum globulin level was 25.4 g/L, which showed 74.4% sensitivity, 71.3% specificity, and 73.3% accuracy. Conclusion: The baseline low serum globulin level is associated with AF recurrence after first-time ablation in lone AF patients. Therefore, it may be used as a predictor of AF recurrence in these patients. |
8. | Impact of serum erythropoietin level on collateral vessel development in patients with coronary artery disease Nil Özyüncü, Sadi Güleç, Çağdaş Özdöl, Başar Candemir, Aydan Ongun, Cansın Tulunay Kaya, Çetin Erol PMID: 28315563 PMCID: PMC5469086 doi: 10.14744/AnatolJCardiol.2017.7419 Pages 386 - 391 Objective: Experimental data have shown that Erythropoietin (EPO) stimulates angiogenesis and neovascularization which may result in improved collateral development. The aim of this study was to investigate the association between serum EPO levels and the extent of coronary collaterals. Patient characteristics possibly related with coronary collaterals were also sought. Methods: A total of 256 patients with high grade coronary stenosis or occlusion were evaluated for the extent of coronary collaterals using Rentrop classification. Patients with grade 0 or 1 collaterals were grouped as poor collaterals, while grade 2 or 3 collaterals were grouped as good collaterals. Results: Mean age of the study population was 63 years, 77% were males. Subjects with good collaterals were significantly more likely to have anemia (p=0.038) and stable angina pectoris as clinical presentation (p=0.40). Serum EPO levels were not different among good and poor collateral groups (10.4±9.4 mU/mL vs. 9.7±11 mU/mL, p=0.397). The prevalence of all other cardiovascular risk factors, medications, and angiographic characteristics were similar between the two groups. After adjusting for age, gender, and clinical presentation with stable angina pectoris, presence of anemia persisted to be a significant correlate of the good collateral formation (OR: 1.95; 95%; CI: 1.07–3.54, p=0.029). Conclusion: There has been conflicting results from trials studying the effects of serum EPO on coronary collateral development. The present study, with the largest patient population studying this topic, suggests that presence of anemia, but not serum EPO level, is associated with good collateral development. |
9. | The effect of high-dose steroid treatment used for the treatment of acute demyelinating diseases on endothelial and cardiac functions Mehmet Vedat Çaldır, Güner Koyuncu Çelik, Özgür Çiftçi, İbrahim Haldun Müderrisoğlu PMID: 27965510 PMCID: PMC5469087 doi: 10.14744/AnatolJCardiol.2016.7425 Pages 392 - 397 Objective: The cardiovascular effects of short-term high-dose steroid treatment (pulse steroid treatment) have not yet been clarified. We examined the short- and long-term effects of pulse steroid treatment in demyelinating diseases on endothelial and cardiac functions. Methods: In this prospective study, we included 35 patients (20 females and 15 males; mean age, 32.8±9.3 years) who were not treated with steroids and who were previously diagnosed with multiple sclerosis or neuromyelitis optica. Patients were evaluated before, 1 week after, and 3 months after the steroid treatment. Brachial artery flow-mediated relaxation and cardiac systolic/diastolic function were evaluated using echocardiography to assess physical examination results, carotid intima–media thickness, and endothelial function. Results: There was no difference between biochemical values, systolic function, left ventricular dimensions, and carotid intima–media thicknesses in the three evaluation periods. There were significant increases in the body mass index, body weight, and systolic/diastolic blood pressure measurements at 1 week and 3 months after treatment (p<0.001). There was a significant decrease in brachial artery flow-mediated relaxation at 1 week and 3 months (1 versus 2, p=0.042; 1 versus 3, p=0.003). In Doppler measurements at 1 week and 3 months, there was an increase in mitral A velocity, IVRT, and EDT values and a decrease in the E/A ratio in line with diastolic dysfunction. Conclusion: Pulse steroid therapy used for demyelinating diseases deteriorated endothelial and left ventricular diastolic functions in the early and late periods. Future studies are needed to evaluate the development of cardiovascular mortality and morbidity in patients receiving this type of treatment. |
10. | Investigating the effect of traditional Persian music on ECG signals in young women using wavelet transform and neural networks Behzad Abedi, Ataollah Abbasi, Atefeh Goshvarpour PMID: 28100896 PMCID: PMC5469088 doi: 10.14744/AnatolJCardiol.2016.7436 Pages 398 - 403 Objective: In the past few decades, several studies have reported the physiological effects of listening to music. The physiological effects of different music types on different people are different. In the present study, we aimed to examine the effects of listening to traditional Persian music on electrocardiogram (ECG) signals in young women. Methods: Twenty-two healthy females participated in this study. ECG signals were recorded under two conditions: rest and music. For each ECG signal, 20 morphological and wavelet-based features were selected. Artificial neural network (ANN) and probabilistic neural network (PNN) classifiers were used for the classification of ECG signals during and before listening to music. Results: Collected data were separated into two data sets: train and test. Classification accuracies of 88% and 97% were achieved in train data sets using ANN and PNN, respectively. In addition, the test data set was employed for evaluating the classifiers, and classification rates of 84% and 93% were obtained using ANN and PNN, respectively. Conclusion: The present study investigated the effect of music on ECG signals based on wavelet transform and morphological features. The results obtained here can provide a good understanding on the effects of music on ECG signals to researchers. |
11. | Heart rate variability in normal-weight patients with polycystic ovary syndrome Celal Kilit, Türkan Paşalı PMID: 28315565 PMCID: PMC5469089 doi: 10.14744/AnatolJCardiol.2017.7473 Pages 404 - 409 Objective: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. The aim of the study was to assess the reactivity of cardiac sympathovagal balance in normal-weight women with PCOS by heart rate variability analysis. Methods: We examined the heart rate variability in 60 normal-weight women with PCOS and compared them with that in 60 age-matched healthy women having a similar metabolic profile. Time and frequency domain parameters of heart rate variability were analyzed based on 5-min-long continuous electrocardiography recordings for the following 3 periods: (1) during rest in supine position, (2) during controlled breathing, and (3) during isometric handgrip exercise. Results: Time and frequency domain parameters of heart rate variability for the 3 periods assessed were similar in the two groups. Although modified Ferriman–Gallwey score and serum testosterone and luteinizing hormone levels were significantly higher in women with PCOS, homeostatic model assessment-insulin resistance (HOMA-IR) was not different the between the PCOS and control groups. There were no significant correlations between serum testosterone levels and heart rate variability parameters among the study population. Conclusion: The findings of this study suggest that the reactivity of cardiac sympathovagal balance is not altered in normal-weight women with PCOS having a normal HOMA-IR. |
EDITORIAL COMMENT | |
12. | Heart rate variability in normal-weight patients with polycystic ovary syndrome Renza Perini PMID: 28529287 PMCID: PMC5469090 doi: 10.14744/AnatolJCardiol.2017.24541 Pages 410 - 411 Abstract |Full Text PDF |
CASE REPORT | |
13. | Kounis syndrome not induced but prevented by the implantation of a drug-eluting stent: a case report Kadriye Terzioğlu, Dane Ediger, Raziye Tülümen Öztürk, Eda Durmuş, Mehmet Fethi Alışır PMID: 28529288 PMCID: PMC5469091 doi: 10.14744/AnatolJCardiol.2017.7690 Pages 412 - 413 Abstract |Full Text PDF |
LETTER TO THE EDITOR | |
14. | Extracorporeal cardiopulmonary resuscitation after pediatric cardiac surgery Orhan Gökalp, Yüksel Beşir, Hasan İner, Levent Yılık, Ali Gürbüz PMID: 28529289 PMCID: PMC5469092 doi: 10.14744/AnatolJCardiol.2017.7715 Page 414 Abstract |Full Text PDF |
15. | Author`s Reply Ersin Erek PMID: 28529290 PMCID: PMC5469093 Pages 414 - 415 Abstract |Full Text PDF |
16. | Epicardial adipose tissue and atrial fibrillation: The other side of the coin Massimo Leggio, Paolo Severi, Stefania D’emidio, Andrea Mazza PMID: 28529291 PMCID: PMC5469094 doi: 10.14744/AnatolJCardiol.2017.7752 Pages 415 - 416 Abstract |Full Text PDF |
17. | Author`s Reply Sinan Altan Kocaman PMID: 28529292 PMCID: PMC5469095 Page 416 Abstract |Full Text PDF |
18. | P2Y12 inhibition after thrombotic thrombocytopenic purpura remission Serkan Kahraman, Murat Ziyrek PMID: 28529293 PMCID: PMC5469096 doi: 10.14744/AnatolJCardiol.2017.7772 Pages 416 - 417 Abstract |Full Text PDF |
19. | Author`s Reply Ali Doğan PMID: 28529282 PMCID: PMC5469097 Page 417 Abstract |Full Text PDF |
20. | IRAK-4 Variants in acute coronary syndrome patients Arzu Ergen, Osman Fazlıoğulları, Cem Başaran, Faruk Çelik, Gonca Candan, Özlem Timirci Kahraman, Ümit Zeybek PMID: 28529283 PMCID: PMC5469098 doi: 10.14744/AnatolJCardiol.2017.7795 Pages 417 - 418 Abstract |Full Text PDF |
E-PAGE ORIGINAL IMAGES | |
21. | Multimodality imaging of huge coronary cameral fistula Bayram Arslan, Mustafa Oylumlu, Ebru Tekbaş, Hasan Kaya PMID: 28529284 PMCID: PMC5469099 doi: 10.14744/AnatolJCardiol.2017.7806 Page E4 Abstract |Full Text PDF |
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