ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 16 Issue : 9 Year: 2016
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
The Anatolian Journal of Cardiology The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(3): 221-226 | DOI: 10.5152/akd.2013.067  

The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study

İstemihan Tengiz1, Uğur Önsel Türk2, Emin Alioğlu2, Bahadır Kırılmaz3, Gülden S. Tamer4, Nurullah Tüzün2, Ertuğrul Ercan5
1Department of Cardiology, Faculty of Medicine, İzmir University, İzmir-Turkey
2Clinic of Cardiology, Central Hospital, İzmir-Turkey
3Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale-Turkey
4Department of Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli-Turkey
5Department of Cardiology, Faculty of Medicine, University of İzmir, İzmir-Turkey

Objective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF). Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients. The study was designed to investigate the possible association of these markers in non-cachectic patients with newly diagnosed systolic heart failure. Methods: Fifty-seven systolic HF patients and 20 matched controls were enrolled in an observational cross-sectional study. Physical and echocardiographic examinations were performed and serum Adp, NT-proBNP, tumor necrosis factor-alpha (TNF-α) levels were measured. Study variables were compared between the groups. Correlation analyses were done and the diagnostic validity of the markers was compared with ROC analysis. Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19±12.9 vs. 7.65±4.6 μg/mL; p<0.001 and 1051.74±606.2 vs. 222.53±65.6 pg/mL; p=0.002; respectively). TNF-α levels were similar between the groups (2.83±1.8 vs. 2.08±1.2 pg/mL; p=0.582). Correlation analysis showed significant association among Adp and NT-proBNP levels, (r=0.448; p<0.001), and left ventricular ejection fraction (LVEF) values (r=-0.466; p<0.001). The Adp and NT-proBNP showed comparable diagnostic performances with mean [95% confidence interval] areas under the curves of 0.857 (0.771-0.944) and 0.888 (0.815-0.960), respectively. Conclusion: There were significant correlation between Adp levels with NT-proBNP levels and LVEF values but no any association between Adp levels with body mass index values and TNF-α levels in patients with newly diagnosed systolic heart failure. The result may arouse suspicion about the hypothesis, which proposes that Adp levels simply reflects disease severity or cardiac cachexia in patients with HF.

Keywords: Heart failure, adiponectin, NT-ProBNP, cardiac cachexia, diagnostic accuracy


İstemihan Tengiz, Uğur Önsel Türk, Emin Alioğlu, Bahadır Kırılmaz, Gülden S. Tamer, Nurullah Tüzün, Ertuğrul Ercan. The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study. Anatol J Cardiol. 2013; 13(3): 221-226


TOOLS
Full Text PDF (English)
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2016 Turkish Society of Cardiology