The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: an observational studyMehmet Tahir Gökdemir1, Halil Kaya2, Özgür Söğüt2, Zekeriya Kaya3, Levent Albayrak4, Abdullah Taşkın5
1Departments of Emergency Medicine Faculty of Medicine, Harran University, Şanlıurfa-Turkey
2Department of Emergency Medicine of Medicine, Harran University, Şanlıurfa-Turkey
3Department of Cardiology Faculty of Medicine, Harran University, Şanlıurfa-Turkey
4Department of Emergency Medicine Faculty of Medicine, Harran University, Şanlıurfa-Turkey
5Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Şanlıurfa-Turkey
Objective: We aimed to assess the role of oxidative stress (OS) and inflammation in the early evaluation of initial acute non -ST -elevation myocardial infarction (NSTEMI) compared with unstable angina pectoris (USAP).
Methods: Forty-seven (54%) patients with NSTEMI and 40 (46%) with (USAP) were included in this cross-section observational study. We assessed the oxidative stress and inflammation parameters. Statistical analysis was performed using Fishers exact test, Chi-square test, Mann-Whitney U test, Students t-test, and Pearson correlation analysis for assess the correlations between variables.
Results: Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p<0.001 for both comparisons), in patients with NSTEMI. In addition, white blood cell count (WBC) and high-sensitive C-reactive protein (hs-CRP) levels were significantly higher in patients with NSTEMI (respectively; p<0.001, p=0.02). Age, WBC and low- density lipoprotein cholesterol showed positive correlations with TOS level (Pearson correlation coefficient: r=0.290, p=0.006; r=0.431, p<0.001; r=0.219, p=0.042 respectively), and also age showed positive correlation with OS index (Pearson correlation coefficient; r=0.246; p=0.021). However, the values of the troponin I and creatine kinase-MB fraction did not differ between the two groups (p>0.05 for all).
Conclusion: TOS, OSI, WBC and CRP levels are significantly higher in NSTEMI subject. These data suggest that inflammatory processes and oxidative stress together play a role in the pathogenesis of acute NSTEMI. Keywords: Oxidative stress, non -ST-elevation myocardial infarction, inflammation parameters
Mehmet Tahir Gökdemir, Halil Kaya, Özgür Söğüt, Zekeriya Kaya, Levent Albayrak, Abdullah Taşkın. The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: an observational study. Anatol J Cardiol. 2013; 13(2): 131-136