ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 19 Issue : 1 Year: 2018
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
The Anatolian Journal of Cardiology Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD [Anatol J Cardiol]
Anatol J Cardiol. 2015; 15(12): 981-989 | DOI: 10.5152/akd.2015.5849  

Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD

Atena Ramezani1, Fariba Koohdani1, Abolghasem Djazayeri2, Ebrahim Nematipour3, Seyed Ali Keshavarz4, Ali-Akbar Saboor-Yaraghi1, Mohammad-Reza Eshraghian5, Abbas Yousefinejad1, Hassan Javanbakht1, Mahnaz Zarei1, Sanaz Gholamhosseini1, Mahmoud Djalali1
1Department of Molecular and Cellular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran
2Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran
3Department of Cardiology, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran
4Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran
5Department of Biostatistics, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran

Objective: Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD). Methods: This randomized, double-blind, placebo-controlled trial included 67 male patients with CAD. First of the four group of participants received 4 g/day omega-3 fatty acids plus 400 IU/day vitamin E (OE), second group 4 g/day omega-3 fatty acids plus vitamin E placebo (OP), or both omega-3 fatty acid and vitamin E placebos (PP) for 8 weeks. Adiponectin gene expression and serum adiponectin and FABP4 levels were evaluated. Results: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. In the OP group, serum adiponectin levels did not change significantly. Consumption of omega-3 fatty acids with and without vitamin E had no significant effect on adiponectin gene expression. Conclusion: Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. This nutritional intervention may prevent complications in patients with CAD because of increased adiponectin levels.

Keywords: coronary artery disease, omega-3 fatty acids, vitamin E, adiponectin, adipocyte fatty acid-binding protein


Atena Ramezani, Fariba Koohdani, Abolghasem Djazayeri, Ebrahim Nematipour, Seyed Ali Keshavarz, Ali-Akbar Saboor-Yaraghi, Mohammad-Reza Eshraghian, Abbas Yousefinejad, Hassan Javanbakht, Mahnaz Zarei, Sanaz Gholamhosseini, Mahmoud Djalali. Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Anatol J Cardiol. 2015; 15(12): 981-989


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright 2016 Turkish Society of Cardiology