The Anatolian Journal of Cardiology
Original Investigation

Analysis of geographical variations in the epidemiology and management of non-valvular atrial fibrillation: results from the RAMSES registry


Department of Cardiology, Faculty of Medicine, Muğla Sıtkı Koçman University; Muğla-Turkey


Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Hospital, İstanbul-Turkey


Department of Cardiology, Bandırma State Hospital; Balıkesir-Turkey


Department of Cardiology, Ankara Keçiören Education and Research Hospital; Ankara-Turkey


Department of Cardiology, Mersin Private Doğuş Hospital; Mersin-Turkey

Anatol J Cardiol 2017; 18: 273-280
DOI: 10.14744/AnatolJCardiol.2017.7709
Read: 252 Downloads: 152 Published: 01 July 2021

Objective: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical regions of Turkey. Methods: In total, 6273 patients were enrolled to this prospective, observational RAMSES study. The patients were divided into seven groups based on the geographical region of residence. Results: In terms of the geographical distribution of the overall Turkish population, the highest number of patients were enrolled from Marmara (1677, 26.7%). All demographic characteristics were significantly different among regions. Preferred oral anticoagulants (OACs) also differed between geographical regions; non-vitamin K OACs were preceded by warfarin in East Anatolia, Aegean, Southeast Anatolia, and Black Sea. Nearly one-third of the patients (28%) did not receive any OAC therapy. However, the number of patients not receiving any OAC therapy was higher in Southeast Anatolia (51.1%) and East Anatolia (46.8%) compared with other geographical regions of Turkey. Inappropriate use of OACs was also more common in East and Southeast Anatolia. Conclusion: This study was the first to show that the demographic differences among the geographical regions may result in different preferences of stroke prevention strategies in Turkey. OACs are still under- or inappropriately utilized, particularly in the eastern provinces of Turkey.

ISSN 2149-2263 EISSN 2149-2271