The Anatolian Journal of Cardiology
Original Investigation

Duration of Ciprofloxacin Use Is Important in the Development of Abdominal Aortic Aneurysm in a Rat Model

1.

Department of Medical Pharmacology, Faculty of Medicine, Marmara University, İstanbul, Turkey

2.

Faculty of Medicine, Marmara University, İstanbul, Turkey

3.

Department of Histology and Embryology, Faculty of Medicine, Marmara University, İstanbul, Turkey

4.

Department of Radiology, Faculty of Medicine, Marmara University, İstanbul, Turkey

Anatol J Cardiol 2022; 26: 810-817
DOI: 10.5152/AnatolJCardiol.2022.1939
Read: 123 Downloads: 84 Published: 01 November 2022

Background: Recent findings suggest that fluoroquinolones, most prescribed antibiotic to treat various infections, have increased abdominal aortic aneurysm formation. We aimed to investigate the relation of the development of abdominal aortic aneurysm and the duration of ciprofloxacin use.

Methods: Male Sprague–Dawley rats were divided into 2 groups to administer saline to the control groups and CaCl2 to the aneurysm groups. These groups were then divided into 3 subgroups: intraperitoneal saline, ciprofloxacin for 2 weeks, and ciprofloxacin for 4 weeks. At the end of 4 weeks, the diameter of abdominal aorta was determined by ultrasonography and animals were sacrificed to obtain abdominal aorta specimens. Elastic fiber fracture, tunica media layer thickness, and aortic tissue damage were evaluated histologically.

Results: Aortic diameter of control-saline (2.15 mm ± 0.06), control-2 weeks (2.25 mm ± 0.06), and control-4 weeks (3.31 mm ± 0.09) ciprofloxacin groups was significantly different (P < .0001). Also, aortic diameter of aneurysm-saline (2.07mm ± 0.02), aneurysm-2 weeks ciprofloxacin (3.33 mm ± 0.64), and aneurysm-4 weeks ciprofloxacin (8.55 mm ± 1.70) groups showed significant increase in aortic diameter with increasing duration of ciprofloxacin use (P < .01). A significant difference was found between the control-saline (0.00 ± 0.00), control-2 weeks (1.50 ± 0.33), and control-4 weeks ciprofloxacin groups (1.57 ± 0.20) in the histological aneurysm scores (P < .001). Aortic tunica media thickness did not change between control-saline and control-ciprofloxaci n groups (P > .05).

Conclusion: The study showed that ciprofloxacin caused injury in the aortic wall but not a significant change in the thickness of the aortic tunica media layer. The duration of ciprofloxacin use was important in the development of aneurysm and aneurysm severity.

Cite this article as: Çulpan Y, Keçeci İ, Sandıkçı İ, et al. Duration of ciprofloxacin use is important in the development of abdominal aortic aneurysm in a rat model. Anatol J Cardiol. 2022;26(11):810-817.

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ISSN 2149-2263 EISSN 2149-2271