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Neutrophil gelatinase-associated lipocalin levels in right and left heart failure: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(6): 498-503 | DOI: 10.5152/akd.2011.133

Neutrophil gelatinase-associated lipocalin levels in right and left heart failure: an observational study

Fatih Koca1, İbrahim Halil Tanboğa2, Mehmet Mustafa Can3, Alper Özkan1, Nurşen Keleş1, Hacer Ceren Tokgöz4, Tahir Bezgin1, Cihangir Kaymaz5
1Clinic of Cardiology, Kartal Koşuyolu Yüksek İhtisas Education and Research Hospital, İstanbul-Turkey
2Clinic of Cardiology, Erzurum Education and Research Hospital, Erzurum-Turkey
3Department of Cardiology, GATA Haydarpaşa Education and Research Hospital, İstanbul-Turkey
4Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye
5Department of Cardiology, Kartal Koşuyolu Yüksek İhtisas Education and Research Hospital, İstanbul, Turkey

Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is a novel marker for early detection of renotubular deterioration. Despite the limited data concerning the NGAL in heart failure (HF), significance of NGAL in right-sided HF remains unknown. We assessed serum and urinary NGAL in left and right-sided HF due to non-ischemic cardiomyopathy (NICMP) and severe pulmonary arterial hypertension (PAH). Methods: In this cross-sectional observational study, we compared three groups; 35 patients with NICMP, 28 patients with PAH and 27 healthy controls. None had a serum creatinine ≥1.5 mg/dL. Plasma brain natriuretic peptide (BNP) levels, estimated glomerular filtration rate (eGFR) by Cockroft-Gault (CG) and Modification of Diet in Renal Disease Study formulas, echocardiographic measures of left and right ventricles (LV, RV) and non-invasive measurement of cardiac index (CI) by echocardiography and impedance cardiography were assessed. Differences among the groups for continuous variables were evaluated by the ANOVA and the Kruskal-Wallis test as appropriate. The Chi-square test was used for comparison of categorical variables. Results: Despite eGFR with CG formula was lower in NICMP and PAH subsets as compared to those in controls (102±27 and 99.4±29.4 vs 122.4±25.9 mL/min, p<0.05 and p<0.005 in order), serum NGAL [141 (113-151), 174 (130-192) and 132 (95-181) ng/mL] and urinary NGAL [15 (12-18), 15 (12-22) and 13 (8-18) ng/mL] levels were not different among groups (p=0.15 and p=0.35, respectively). Conclusion: Despite the mildly impaired eGFR in left-sided HF due to NICMP and right-sided HF due to PAH, neither serum, nor urinary NGAL levels are elevated in these patients.

Keywords: Neutrophil gelatinase-associated lipocalin, renotubular, heart failure, glomerular filtration rate, echocardiography

Fatih Koca, İbrahim Halil Tanboğa, Mehmet Mustafa Can, Alper Özkan, Nurşen Keleş, Hacer Ceren Tokgöz, Tahir Bezgin, Cihangir Kaymaz. Neutrophil gelatinase-associated lipocalin levels in right and left heart failure: an observational study. Anatol J Cardiol. 2011; 11(6): 498-503