EDITORIAL | |
1. | Metabolomics and many more… Çetin Erol PMID: 31584439 doi: 10.14744/AnatolJCardiol.2019.10 Page 159 Abstract |Full Text PDF |
META ANALYSIS | |
2. | Intravascular ultrasound versus angiography-guided drug-eluting stent implantation in patients with complex coronary lesions: An updated meta-analysis of nine randomized clinical trials Zhongguo Fan, Mengnan Xu, Yuanyuan Xiao, HuaLing Wang, Bing Xu, Shenghu He PMID: 31584443 doi: 10.14744/AnatolJCardiol.2019.86598 Pages 160 - 167 Abstract |Full Text PDF |
REVIEW | |
3. | Precision medicine: The future of diagnostic approach to pulmonary hypertension? Piotr Kedzierski, Adam Torbicki PMID: 31584446 doi: 10.14744/AnatolJCardiol.2019.97820 Pages 168 - 171 Pulmonary hypertension (PH) is a common finding that can result from many different pathological conditions. Depending on the etiology, treatment may be quite different, but early diagnosis and correct classification of PH is difficult. With an aging population and recently suggested decreased pulmonary arterial pressure threshold defining PH, we are facing even more diagnostic uncertainties. A new approach to patients’ phenotyping is needed. Here we present available data and future perspectives on employing an in-depth analysis of the omics cascade to allow an earlier and more reliable diagnosis and classification of PH. Indeed, with the help of super-fast computing, it became possible to simultaneously consider the levels of thousands of potential biomarkers to find patterns specific for clinically suspected disease. The omics cascade is an invaluable source of information. However, while the genome can be perceived as providing possibilities, transcriptome–as carving them this is metabolome that may tell us “what is really going on” in an individual living organism. Metabolomics research requires blinded search for characteristic patterns of discreet changes in the levels of detectable metabolites. Since as many as 40,000 various substances are produced as a “side effect of staying alive”, metabolite profiling can be compared to fishing up for organized signals in a universe of chaos. Although difficult, such search for metabolic patterns that might lead to replacing the term biomarker by metabolic fingerprinting in the area of pulmonary circulation has already begun. |
ORIGINAL INVESTIGATION | |
4. | The better substitute for tricuspid valve replacement in patients with severe isolated tricuspid regurgitation Weitao Liang, Honghua Yue, Tao Li, Xiaoli Qin, Yongjun Qian, Zhong Wu PMID: 31584434 doi: 10.14744/AnatolJCardiol.2019.47381 Pages 172 - 176 Objective: The ideal alternative for tricuspid valve replacement (TVR) in patients with severe isolated tricuspid regurgitation remains unclear. The aim of the present study was to retrospectively investigate the outcomes of using bioprosthetic and mechanical valves at the tricuspid position. Methods: A total of 98 consecutive patients without left-side cardiac disease or history of heart surgery who underwent first-time TVR between January 2010 and March 2017 at the West China Hospital, China were included in the study. Patient data, including all-cause death and need for tricuspid valve reoperation as the main end points, were retrospectively evaluated. Results: A total of 76 patients were enrolled into the study. The mean follow-up period was 43.3±21.9 (10–87) months. The mean age of the patients was 45.7±13.4 years. The study comprised 32.9% of male patients. During the follow-up period, 4, 3, 12, and 3 cases of death, reoperation, prosthesis dysfunctions, and prosthesis-related thrombosis were noted, respectively. Biological and mechanical valves were used in 56.6% and 43.4% of the patients, respectively. However, there was no significant difference between mechanical and biological valves with respect to echocardiographic date and survival, reoperation, prosthetic valve dysfunction, and thromboembolism rate. Conclusion: TVR is not a very high-risk procedure in patients with isolated tricuspid regurgitation, and the decision for prosthesis implantation in TVR should be made on an individual basis according to suitable clinical judgment. |
5. | Relationship of serum salusin beta levels with coronary slow flow Aydın Akyüz, Fatma Aydın, Şeref Alpsoy, Demet Ozkaramanli Gur, Savas Guzel PMID: 31584433 doi: 10.14744/AnatolJCardiol.2019.43247 Pages 177 - 184 Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-β is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-β levels in CSF and its correlation with CSF. Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-β and thrombolysis in myocardial infarction frame count (TFC). Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80±1.2 vs. 2.21±1.2 mg/dL, p=0.011), salusin-β [1205 (330–2092) vs. 162 (29–676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29±9 vs. 19.7±3.7, p<0.001), circumflex artery TFC (25±10 vs. 15±3.2, p<0.001), right coronary artery TFC (28±7.1 vs. 13±3.3, p<0.001), and mean TFC (28±4.4 vs. 16±3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized β±SE=0.178±0.08, p=0.036) and salusin-β levels (unstandardized β±SE=0.006±0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-β and mean TFC values (r=0.564; p<0.001). Conclusion: There is an association between serum salusin-β levels and CSF. |
6. | Assessment of subclinical atherosclerotic cardiovascular disease in patients with ankylosing spondylitis Erdinç Hatipsoylu, İlker Şengül, Taciser Kaya, Altınay Göksel Karatepe, Seniz Akçay, Leyla Isayeva, Giray Bozkaya, Erhan Tatar PMID: 31584431 doi: 10.14744/AnatolJCardiol.2019.13367 Pages 185 - 191 Objective: The aim of the present study was to compare patients with ankylosing spondylitis (AS) with healthy controls with respect to subclinical atherosclerotic cardiovascular disease (CVD). Methods: A total of 44 patients with AS with no history of CVD, diabetes mellitus, hypertension, chronic kidney disease, and lipid-lowering drug use were compared with 40 age- and sex-matched healthy controls with respect to carotid intima-media thickness (CIMT) and pulse wave velocity (PWV), which are surrogate markers of subclinical atherosclerosis. Correlation analysis was also performed to examine the association between surrogate markers and disease activity with inflammation [Ankylosing spondylitis disease activity score with C-reactive protein (ASDAS-CRP)]. Results: In addition to age and sex, both groups were comparable with respect to cigarette smoking, body mass index, and high-density lipoprotein cholesterol (p=0.425, p=0.325, and p=0.103, respectively). The level of total cholesterol was significantly lower in patients with AS (p=0.002). Nonsteroidal anti-inflammatory drug and tumor necrosis factor alpha inhibitor use ratios in patients with AS were 79.5% and 65.9%, respectively. There was no significant difference between both groups regarding PWV and CIMT (p=0.788 and p=0.253, respectively). In patients with AS, there was a significant correlation between ASDAS-CRP and CIMT (r=0.315, p=0.038), but the correlation between ASDAS-CRP and PWV was not significant (r=−0.183, p=0.234). Conclusion: The results of the present study could not provide sufficient evidence whether disease activity with inflammation caused subclinical atherosclerotic CVD in patients with AS without overt CVD. The increased atherosclerotic CVD risk is most probably multifactorial in patients with AS, but the extent of the contribution of disease activity with inflammation to increased atherosclerosis is controversial. |
EDITORIAL COMMENT | |
7. | Subclinical atherosclerosis: A hidden threat for patients with ankylosing spondylitis Wafa Hamdi, Kaouther Maatallah PMID: 31584441 doi: 10.14744/AnatolJCardiol.2019.78703 Pages 192 - 193 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
8. | Frontal QRS-T angle is related with hemodynamic significance of coronary artery stenosis in patients with single vessel disease Serkan Kahraman, Ali Kemal Kalkan, Ayse Beril Turkyilmaz, Arda Can Dogan, Yalcin Avci, Fatih Uzun, Mehmet Erturk PMID: 31584447 doi: 10.14744/AnatolJCardiol.2019.99692 Pages 194 - 201 Objective: Fractional flow reserve (FFR) measurement is used to decide the hemodynamic significance of coronary artery lesion. QRS-T angle (QRSTa) is a novel marker of myocardial repolarization abnormality and is affected by obstructive coronary artery disease. The aim of the present study was to evaluate the association between QRSTa and coronary FFR measurement in patients with isolated left anterior descending (LAD) artery stenosis. Methods: A total of 197 patients undergoing FFR measurement for isolated LAD artery stenosis were retrospectively enrolled in the present study. According to FFR value, patients were divided into two groups as 139 patients with normal FFR (>0.80, group 1) and 58 patients with low FFR (≤0.80, group 2). A 12-lead surface electrocardiography of all subjects that had been recorded before performing coronary angiography was evaluated to measure QRSTa, as well as baseline demographic and clinical variables. Results: The mean age of group 2 was significantly higher than that of group 1 (61±11 and 64±11, p=0.044). While there were no differences in heart rate, QRS duration, and corrected QT interval between the two groups, QT interval [377 (359–397) and 379 (367–410), p=0.045] and frontal QRSTa [59 (10–120) and 86 (22–132), p<0.001] were higher in group 2. QT interval [odds ratio (OR)=1.046, 95% confidence interval (CI)=1.010–1.084, p=0.012] and frontal QRSTa (OR=1.025, 95% CI=1.010–1.041, p=0.001) were found to be independent predictors of low FFR value in multivariate logistic regression analysis. Conclusion: In the present study, FFR measurement was demonstrated to be correlated with wide QRSTa as a noninvasive and easy method. Thus, we suggest that the results of FFR measurement as an invasive modality can be previously predicted with a simple electrocardiographic evaluation, such as QRSTa. |
CASE REPORT | |
9. | Mobitz type II, 2: 1 atrioventricular block mimicking as a convulsive seizure Çağlar Kaya, Utku Zeybey, Meliha Akpınar, Gokay Taylan, Fatih Mehmet Uçar PMID: 1584444 doi: 10.14744/AnatolJCardiol.2019.88646 Pages 202 - 203 Abstract |Full Text PDF |
10. | Unusual complication of carotid artery stenting as the result of a proximal emboli protection device (the Mo.Ma): Iatrogenic common carotid artery dissection Fatih Gungoren, Feyzullah Besli, Zulkif Tanriverdi, Ozcan Kocaturk, Mustafa Begenc Tascanov PMID: 31584432 doi: 10.14744/AnatolJCardiol.2019.33238 Pages 203 - 206 Abstract |Full Text PDF |
11. | Mitral valve and right ventricular thrombi possibly caused by heparin-induced thrombocytopenia Ahmet Güner, Anıl Avcı, Abdulkadir Uslu, Semih Kalkan, Mehmet Özkan PMID: 31584437 doi: 10.14744/AnatolJCardiol.2019.65712 Pages 206 - 209 Abstract |Full Text PDF | Video |
LETTER TO THE EDITOR | |
12. | Angiogenin and osteopontin and coronary collateral circulation Joob Beuy, Viroj Wiwanitkit PMID: 31584435 doi: 10.14744/AnatolJCardiol.2019.53248 Page 210 Abstract |Full Text PDF |
13. | Author`s Reply Kadri Murat Gurses, Muhammed Ulvi Yalcin, Duygu Kocyigit PMID: 31584442 Pages 210 - 211 Abstract |Full Text PDF |
14. | Methodological problems in the measurement of interleukin-33 concentrations in patients with heart failure with a reduced ejection fraction Berhan Keskin, İsmail Balaban, Seda Tanyeri, Özgür Yaşar Akbal, Ali Karagöz PMID: 31584436 doi: 10.14744/AnatolJCardiol.2019.59387 Page 211 Abstract |Full Text PDF |
15. | Author`s Reply Oliwia Anna Segiet, Ewa Romuk, Ewa Nowalany- Kozielska, Celina Wojciechowska, Adam Piecuch, Romuald Wojnicz PMID: 31584445 Page 212 Abstract |Full Text PDF |
E-PAGE ORIGINAL IMAGES | |
16. | Cangrelor bridging strategy for liver damage after mechanical chest compression Alberto Francesco Cereda, Nuccia Morici, Paolo Aseni, Osvaldo Chiara PMID: 31584440 doi: 10.14744/AnatolJCardiol.2019.78546 Pages E8 - E9 Abstract |Full Text PDF |
17. | Bilateral coronary artery–pulmonary artery fistulas with a giant coronary aneurysm Qingyu Ji, Ruijuan Han, Kai Sun PMID: 31584438 doi: 10.14744/AnatolJCardiol.2019.66562 Pages E9 - E10 Abstract |Full Text PDF | Video |
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