EDITORIAL | |
1. | Mental stress-induced myocardial ischemia, resistant hypertension, cardiovascular risk in metabolic syndrome from the PURE cohort, and more Çetin Erol PMID: 32870179 doi: 10.14744/AnatolJCardiol.2020.9 Page 125 Abstract |Full Text PDF |
REVIEW | |
2. | Research progress regarding the diagnosis and treatment of mental stress-induced myocardial ischemia Na Huan, Yonghui Yu, Peili Wang, Chenglong Wang PMID: 32870175 doi: 10.14744/AnatolJCardiol.2020.69447 Pages 126 - 136 Myocardial ischemia resulting from psychological stress [mental stress-induced myocardial ischemia (MSIMI)] refers to the condition wherein psychosocial and psychological stimulations cause myocardial ischemia in patients with coronary heart disease, which is different from drug-induced myocardial ischemia. Therefore, this condition often escapes diagnosis, portends clinical risk, and affects the quality of life of MSIMI survivors. MSIMI is closely related to the poor prognosis of cardiovascular diseases, especially in young women, according to recent randomized, controlled trials (RCTs) on MSIMI. These RCTs involved different sample sizes, interventional measures, and detection techniques. Moreover, differences exist regarding the prevalence rate, distribution characteristics, possible pathogenesis, and clinical significance. Nevertheless, currently, the diagnostic criteria, pathogenesis, and treatment of MSIMI are still in the clinical exploration stage. Hence, considering recent RCTs, this paper summarizes the research status of MSIMI from the aspects of pathogenesis, diagnosis, and treatment strategies to provide a theoretical basis for the follow-up diagnostic methods and treatment guidelines for MSIMI. |
CONSENSUS REPORT | |
3. | Consensus paper on the evaluation and treatment of resistant hypertension by the Turkish Society of Cardiology Asife Sahinarslan, Emine Gazi, Meryem Aktoz, Cigdem Ozkan, Gülay Ulusal Okyay, Ozgul Ucar Elalmis, Erdal Belen, Reviewers: Atila Bitigen, Ulver Derici, Neslihan Bascil Tutuncu, Aylin Yildirir PMID: 32870176 doi: 10.14744/AnatolJCardiol.2020.74154 Pages 137 - 152 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
4. | Comparison of the effects of coronary artery anastomosis training between senior and junior surgeons Bo Li, Xiaokang Luo, Lei Qi, dong Zhang, Fuliang Luo, Bin Li, Yue Tang PMID: 32870168 doi: 10.14744/AnatolJCardiol.2020.37460 Pages 153 - 159 Objective: Many countries are facing a shortage of cardiac surgeons, who are crucial in meeting the demands of growing number of patients in need of coronary artery bypass grafting. This situation poses a serious challenge, especially in China. The purpose of this study is to determine whether cardiac surgeons are suitable for training in coronary artery anastomosis at an earlier stage in their career. Methods: We divided 12 cardiac surgeons with no prior experience in coronary artery anastomosis into senior and junior groups for training and assessment. All trainees received training in coronary artery anastomosis for a defined period. We performed in vivo and in vitro examinations before and after training, respectively. Additionally, we assessed individual surgical performance of surgeons by using performance rating scores, including different aspects of surgical skills rated on a five-point scale. Results: The post-training scores (overall, junior, senior) were significantly higher than the pre-training scores (overall, junior, and senior). We observed no differences in pre-training and post-training scores between the junior and senior groups. Conclusion: Senior surgeons did not had any significant advantages over junior surgeons with respect to coronary artery anastomosis in the absence of training. Junior surgeons achieved the same results as the senior surgeons after training. |
5. | Dysregulated circulating SOCS3 and haptoglobin expression associated with stable coronary artery disease and acute coronary syndrome: An integrated study based on bioinformatics analysis and case–control validation Xunnan Zhang, Xi Lv, Xiandong Li, Yaping Wang, Hao-yu Lin, Jicai Zhang, Chunyan Peng PMID: 32870172 doi: 10.14744/AnatolJCardiol.2020.56346 Pages 160 - 174 Objective: To extensively use blood transcriptome analysis to identify potential diagnostic and therapeutic targets for cardiovascular diseases. Methods: Two gene expression datasets (GSE59867 and GSE62646) were downloaded from GEO DataSets to identify altered blood transcriptomes in patients with ST-segment elevation myocardial infarction (STEMI) compared to stable coronary artery disease (CAD). Thereafter, several computational approaches were taken to determine functional roles and regulatory networks of differentially expressed genes (DEGs). Finally, the expression of dysregulated two hub genes–suppressor of cytokine signaling 3 (SOCS3) and haptoglobin (HP)–were validated in a case–control study. Results: A total of 119 DEGs were identified in the discovery phase, consisting of 71 downregulated genes and 48 upregulated genes; two hub modules consisting of two hub genes–SOCS3 and HP–were identified. In the validation phase, both SOCS3 and HP were significantly downregulated in the stable CAD and acute coronary syndrome (ACS) patients when compared with healthy controls. Meanwhile, HP was significantly upregulated in STEMI patients when compared with stable CAD patients (p=0.041). Logistic regression analysis indicated that: downregulated expression of HP correlated with increased risk of CAD [odds ratio (OR)=0.52, 95% confidence interval (CI)=0.31~0.87, p=0.013]; and downregulated expression of SOCS3 correlated with increased risk of ACS (OR=0.66, 95% CI=0.46~0.94, p=0.023) when age, gender, history of hyperlipidemia, diabetes and hypertension were included as covariates. Conclusion: Future clarification of how SOCS3 and HP influence the pathogenesis of disease may pave the way for the development of novel diagnostic and therapeutic methods. |
6. | Comparisons of microbiota-generated metabolites in patients with young and elderly acute coronary syndrome Mustafa Begenc Tascanov, Zulkif Tanriverdi, Fatih Gungoren, Feyzullah Besli, Musluhittin Emre Erkus, Ismail Koyuncu, Ataman Gonel, Gulsen Genc Tapar PMID: 32870170 doi: 10.14744/AnatolJCardiol.2020.47995 Pages 175 - 182 Objective: Acute coronary syndrome (ACS) is a leading cause of death worldwide. There is great interest in defining the risk factors and underlying mechanisms of ACS among young people. The microbiota and its metabolites have recently become a popular research topic, yet there is still no study that investigated microbiota-generated metabolites as a possible risk factor in young patients with ACS. In this study, we aimed to investigate the relationship between microbiota-generated metabolites and ACS in young people. Methods: This study included 44 young patients with ACS (<50 years of age), 39 elderly patients with ACS, and 44 patients with normal coronary arteries. Inflammatory parameters and serum trimethylamine N-oxide (TMAO) and choline levels were measured in all patients. Results: Young patients with ACS had significantly higher levels of TMAO and choline compared to the control and elderly ACS groups. Also, elderly patients with ACS had a significantly higher level of TMAO than the control group. Linear regression analysis was performed to determine the independent predictors of TMAO. Two regression models were involved. The first model included young ACS and control groups, while the second model included young and elderly ACS groups. In the first model, we found that young ACS (ß=0.399, p=0.004) and smoking ACS (ß=0.211, p=0.046) were significantly associated with TMAO level. In the second model, young ACS was significantly associated with TMAO level (ß=0.230, p=0.035). Conclusion: In this study, we have shown that young ACS was significantly associated with increased TMAO level. |
7. | The prevalence of major cardiovascular risk factors in a rural population of the Chui region of Kyrgyzstan: The results of an epidemiological study Andrey G Polupanov, Abdimetalip Khalmatov, Aliina Altymysheva, Olga S. Lunegova, Aibek E. Mirrakhimov, Ibragim S. Sabirov, Anna Kontsevaya, Ainagul Dzhumagulova, Erkin Mirrakhimov PMID: 32870173 doi: 10.14744/AnatolJCardiol.2020.59133 Pages 183 - 191 Objective: To study the prevalence of cardiovascular (CV) risk factors (RFs) in the rural population of the Chui region of Kyrgyzstan (Central Asia). Methods: The sample was representative of the population in terms of age and sex and included at least 10% of the population aged 18-65 y. Of the 1,672 people included in the cohort, 1.330 people responded to the invitation (79.5% of the total sample population). All study participants were interviewed using standardized questionnaires and examined by a cardiologist. Blood pressure (BP), weight, height, waist circumference (WC), fasting serum glucose, and fasting lipid level were measured. Results: The prevalence of major CV RFs in the examined sample was as follows: arterial hypertension 34.1%, obesity 25.7%, and abdominal obesity 52.3%; the factors were significantly more prevalent in women (68.2%) and increased with age. The frequency of lipid metabolism disorders was 88.4% in the examined subjects, and an increased level of low-density cholesterol (70.5%) was common. Hypodynamia was detected in 15.6% of the subjects, diabetes mellitus in 3.76%, and a family history of cardiovascular disease was present in 34.8% of the examined subjects. The frequency of smoking was 24.6% and was significantly higher in men (46.9%). Conclusion: Abdominal obesity, followed by hypercholesterolemia and arterial hypertension were the most common RFs among the rural population of the Chui region of Kyrgyzstan. Smoking was the most common RF among men. The prevalence of traditional CV RFs, except smoking, increased with age. |
8. | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) Aytekin Oğuz, Mustafa Kılıçkap, Sadi Güleç, Yüksel Altuntaş, Kubilay Karşıdağ, Ahmet Temizhan, Burcu Çalık Tümerdem, Miraç Vural Keskinler, Sumathy Rangarajan, Salim Yusuf PMID: 32870166 doi: 10.14744/AnatolJCardiol.2020.27227 Pages 192 - 200 Objective: Metabolic syndrome (MetS) includes several cardiovascular (CV) risk factors. This study aimed to assess CV risk of MetS, contribution of its components to the risk, and whether MetS provides additional risk beyond its components. Methods: The Prospective Urban Rural Epidemiology (PURE) Turkey cohort included 3933 individuals aged between 35 and 70 years, with a median follow-up of 8.9 years. MetS was diagnosed as the presence of any of the following criteria: high blood pressure, high fasting plasma glucose, abdominal obesity, low HDL-cholesterol, or high triglycerides. The primary outcome was the composite of fatal CV events, non-fatal myocardial infarction, stroke or heart failure, adjusted for age, sex, smoking, family history of CV diseases, and LDL-cholesterol. Results: The primary outcome was more common in the MetS group [178 (9.2%) vs. 70 (3.5%); corresponding incidence rate of 11.3 vs. 4.2 per 1000 person-years; log-rank p<0.001]. Each component was significantly associated with the primary outcome; however, when the components were sequentially included in the model, abdominal obesity and high triglycerides did not provide additional risk on top of the other three components. The hazard ratio for MetS for the primary outcome was 2.12 (95% confidence interval 1.59–2.81, p<0.001), and the discriminative ability (c-statistics) of the models with MetS and the components was similar. Conclusion: MetS increases the risk of CV events more than two-fold. High blood pressure, high fasting plasma glucose, and low HDL-cholesterol are the top three components of MetS for CV risk. MetS and its components have a similar discriminative ability for CV events. |
CASE REPORT | |
9. | Pyrethroid insecticide-induced takotsubo syndrome İbrahim Yıldız, Pınar Özmen Yıldız, İsmail Gürbak PMID: 32870165 doi: 10.14744/AnatolJCardiol.2020.25668 Pages 201 - 203 Abstract |Full Text PDF | Video |
10. | A simple yet novel solution to prevent stent stripping in Guidezilla use Kerim Esenboga, Kaan Akın, Nil Ozyuncu, Turkan Seda Tan, Durmus Eralp Tutar PMID: 32870167 doi: 10.14744/AnatolJCardiol.2020.36900 Pages 203 - 205 Abstract |Full Text PDF |
11. | Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Arjan Khattar, Ian Beeton PMID: 32870171 doi: 10.14744/AnatolJCardiol.2020.53496 Pages 205 - 208 Abstract |Full Text PDF |
LETTER TO THE EDITOR | |
12. | Unexpected peak of mortality: The COVID-19 burden on Bergamo transcatheter aortic valve implantation register Alberto Cereda, Diego Cugola, Giulio Balestrieri, Angelina Vassileva, Orazio Valsecchi PMID: 32870164 doi: 10.14744/AnatolJCardiol.2020.01955 Pages 209 - 210 Abstract |Full Text PDF |
13. | Paravalvular leak after transcatheter aortic valve implantation Orhan Gökalp, Hasan Iner, Yüksel Beşir, Nihan Karakaş Yeşilkaya, Levent Yılık PMID: 32870174 doi: 10.14744/AnatolJCardiol.2020.65259 Pages 210 - 211 Abstract |Full Text PDF |
14. | Author`s Reply Bilge Duran Karaduman, Hüseyin Ayhan, Telat Keleş, Engin Bozkurt PMID: 32870180 Pages 211 - 212 Abstract |Full Text PDF |
E-PAGE ORIGINAL IMAGES | |
15. | Peripheral angiographic view of severe aortic regurgitation Abdulrahman Naser, Khagani Isgandarov, Tolga Sinan Güvenç PMID: 32870177 doi: 10.14744/AnatolJCardiol.2020.75325 Page E8 Abstract |Full Text PDF | Video |
16. | Inadvertent distal coronary sinus perforation via a large thebesian vein during angiography Halil Akın, Bernas Altıntaş, Serdar Sarıkaya, Hüseyin Ede PMID: 32870169 doi: 10.14744/AnatolJCardiol.2020.40524 Pages E8 - E9 Abstract |Full Text PDF | Video |
17. | Eosinophilic myocarditis: Magnetic resonance imaging -based study of a dramatic response to steroids Aayush Kumar Singal, Jaskaran Singh Gujral, Vineeta Ojha, Satyavir Yadav PMID: 32870178 doi: 10.14744/AnatolJCardiol.2020.87120 Pages E9 - E10 Abstract |Full Text PDF |
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