ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology - Anatol J Cardiol: 28 (5)
Volume: 28  Issue: 5 - May 2024
1.Sodium-Glucose Cotransporter 2 Inhibitors
Çetin Erol
PMID: 38686395  PMCID: PMC11059228  doi: 10.14744/AnatolJCardiol.2024.5  Page 216
Abstract |Full Text PDF

2.Role of Resistance Exercise in Cardiology
Akın Torun
PMID: 38327182  PMCID: PMC11059226  doi: 10.14744/AnatolJCardiol.2023.4073  Pages 217 - 221
Resistance exercise is a form of exercise that increases muscular strength and endurance by exercising a muscle or muscle group against external resistance. Resistance exercises have an important potential in preventing cardiac diseases, increasing treatment efficiency, and improving quality of life. In spite of the fact that the vast majority of cardiology research to date has focused on aerobic exercise, an increasing number of studies on resistance exercise have been published in the past few years. Although resistance exercise was combined with aerobic exercise in most of these studies, its isolated efficacy was also examined. In conditions such as coronary artery disease, peripheral artery disease, heart failure, arrhythmias, and cardiac rehabilitation, resistance exercise (RE) is regarded as a potentially beneficial approach. In addition to interventional and medical treatments, resistance exercise can also be considered as a cost-effective and sustainable method. The effects of resistance exercise on a variety of cardiovascular conditions were investigated in this evaluation of the literature.

3.Do Sodium-Glucose Cotransporter 2 Inhibitors Decrease the Risk of Contrast-Associated Acute Kidney Injury in Patients with Type II Diabetes Mellitus?
Gizem Çabuk, Kutluhan Eren Hazır
PMID: 38506315  PMCID: PMC11059220  doi: 10.14744/AnatolJCardiol.2024.3980  Pages 222 - 228
Background: The risk of contrast-associated acute kidney injury is relatively higher in patients with diabetes mellitus compared to non-diabetics. Recent trials have revealed the renoprotective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors. We aimed to investigate the possible preventive effect of SGLT2 inhibitors against contrast-associated acute kidney injury in the diabetic population who underwent coronary angiography with a diagnosis of stable angina or acute coronary syndrome.

Methods: This was a cross-sectional and single-center study. We enrolled 345 patients with type II diabetes mellitus who were divided into 2 groups: using an SGLT2 inhibitor (group 1; n = 133) in addition to other antidiabetic medication and not using an SGLT2 inhibitor (group 2; n = 212). Both groups were compared in terms of contrast-associated acute kidney injury incidence. We also compared groups for the duration of hospitalization.

Results: Baseline characteristics (age, sex, risk factors and medications) and laboratory findings were similar between the 2 groups. The means of administered contrast volume were also similar (160.42 (± 70.31) mL vs. 158.72 (± 81.24) mL, P = 0.83) between groups 1 and 2, respectively. We found that contrast-associated acute kidney injury incidence was significantly higher in group 2 compared to group 1 (n = 56 (26.4%) vs. n = 12 (9.0%), P < 0.001). The duration of hospitalization was significantly longer in group 2 (3.25 (± 2.03) days) than in group 1 (2.54 (± 1.39) days) (P = 0.001).

Conclusion: We found that contrast-associated acute kidney injury was significantly lower, and the duration of hospitalization was significantly shorter in diabetic patients using SGLT2 inhibitors compared to non-users.

4.The Effect of Empagliflozin on Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway in Patients with Type 2 Cardiorenal Syndrome
Pei Zhou, Xiangyu Tang, Yunxia Deng, Rong Wu, Yuan Yi, Hao Deng, Qiongjiao Cao
PMID: 38445622  PMCID: PMC11059222  doi: 10.14744/AnatolJCardiol.2024.2736  Pages 229 - 235
Background: Empagliflozin (EMPA) demonstrates cardioprotective effects on the patients with heart failure, but its effects in cardiorenal syndrome (CRS) remain unspecified. The purpose of the exploratory study was to investigate the effect of EMPA on patients with type 2 CRS and type 2 diabetes mellitus (DM).

Methods: This study was a randomized trial of patients with type 2 CRS and DM done between December 2020 and January 2022. Patients were randomly allocated to the control group and the EMPA group using EMPA as an add-on treatment. Serum interleukin 6 (IL-6), janus kinase 2 (JAK-2), and signal transducer and activator of transcription 3 (STAT-3) concentrations were measured in 102 patients with CRS and healthy individuals without any disease using enzyme-linked immunosorbent assay before and after treatment. The evaluation of renal function was measured by immunoturbidimetry, and cardiac function was estimated by doppler echocardiography. Rates of adverse events and major adverse cardiac events (MACE) were documented.

Results: The results showed that EMPA decreased the level of IL-6 but increased the level of JAK-2 and STAT-3 in patients. Additionally, the results suggest EMPA significantly reduced the incidence of MACE compared to the control group, while the rate of adverse events did not significantly differed.

Conclusions: Our study suggested that the cardiorenal benefits conferred by EMPA might be driven by anti-inflammatory effects, cooperated with the activation of JAK2/STAT3 signaling pathways, leading to modest short-term improvements in patients with type 2 CRS. The overall safety and low complication make EMPA a significant choice for clinical application.

5.Comprehensive Analysis of Key Endoplasmic Reticulum Stress-Related Genes and Immune Infiltrates in Stanford Type A Aortic Dissection
Wei Zhou, Jun Nie, Dafa Zhang
PMID: 38445624  PMCID: PMC11059230  doi: 10.14744/AnatolJCardiol.2024.4251  Pages 236 - 244
Background: Type A aortic dissection is a fatal disease. However, the role of endoplasmic reticulum stress-related genes (ERSRGs) in type A aortic dissection has not yet been fully clarified.

Methods: Differentially expressed genes in the aorta of type A aortic dissection patients were analyzed based on the GSE52093 database. The ERSRGs were downloaded from the GeneCards website. Functional enrichment analysis and protein–protein interaction analysis were performed on the acquired differentially expressed ERSRGs. The mRNA expression of the 5 top key differentially expressed ERSRGs was further explored in GSE153434 and clinical samples. Immune infiltration correlation analysis was performed on the validated key genes. Finally, we constructed regulatory networks of transcription factors, miRNAs, and chemicals.

Results: Twelve differentially expressed ERSRGs were identified, of which 8 genes were downregulated and 4 genes were upregulated. GeneMANIA was adopted to analyze these genes and their interacting proteins, and the results showed that the main function was calcium ion transport. Four key genes, ACTC1, CASQ2, SPP1, and REEP1, were validated in GSE153434 and clinical samples. The area under the ROC curve values for ACTC1, CASQ2, SPP1, and REEP1 were 0.92, 0.96, 0.89, and 1.00, respectively. ACTC1 and REEP1 correlated with multiple immune cells. Many transcription factors, microRNAs, and chemicals were identified with the potential to regulate these 4 key genes.

Conclusion: In this study, we identified 12 differentially expressed ERSRGs by analyzing the Gene Expression Omnibus database. Four key genes may influence the development of type A aortic dissection by regulating endoplasmic reticulum stress. These results expand our understanding of type A aortic dissection, and the 4 key genes are expected to be diagnostic markers and potential therapeutic targets.

6.Publication Trends on Infective Endocarditis: Comprehensive Bibliometric Analysis and Visualization Between 1892 and 2022
Yağmur Ekenoğlu Merdan, Okan Aydoğan
PMID: 38506314  PMCID: PMC11059227  doi: 10.14744/AnatolJCardiol.2024.4277  Pages 245 - 254
Background: In recent years, studies reported that the incidence of infective endocarditis (IE) has increased despite the decrease in rheumatic heart diseases, great advances in medical and surgical treatment methods, and prophylactic antibiotic therapies. However, there is no bibliometric analysis based on the visual mapping method in the literature. In the study, we aimed to analyze the hot topics in IE, the distribution of publications in terms of country, institution, journal, author, and their relationships by assessing IE articles published in the 130 years between 1892 and 2022.

Methods: Publications before 2023 were analyzed using the keywords “infective” and “endocarditis” in the Scopus database.

Results: Approximately 25% of the publications on IE were from the USA followed by Japan, France, and the UK. A total of 116 keywords were used at least 15 times and the keywords were categorized into 9 clusters by the VOSviewer program. The keywords used more than 100 times except “infective endocarditis” were “echocardiography,” “mortality,” “surgery,” “Staphylococcus aureus,” “cardiac surgery,” “epidemiology,” and “prognosis” 247, 191, 152, 142, 130, 122, and 119 times, respectively. To the best of our knowledge, the study is the most comprehensive study globally on IE with the widest time range including the visual mapping method.

Conclusion: Since our study reveals the changes in the literature related to infective endocarditis, we think that it will be a guide in planning new research studies. We believe that periodic repetition of bibliometric analyses and keyword mapping studies will contribute to the quantitative and qualitative development of scientific productivity globally.

7.Factors Influencing the Risk of No-Reflow Development
Yücel Kanal
PMID: 38445623  PMCID: PMC11059231  doi: 10.14744/AnatolJCardiol.2024.4224  Pages 255 - 256
Abstract |Full Text PDF

8.Reply to Letter to the Editor: “Factors Influencing the Risk of No-Reflow Development”
İbrahim Etem Çelik, Mikail Yarlıoğlu, Ozan Barutçu, Onur Akgün, Mustafa Duran, Şükrü Yorulmaz, Selçuk Öztürk, Sani Namık Murat
PMID: 38430116  PMCID: PMC11059221  doi: 10.14744/AnatolJCardiol.2024.4226  Page 257
Abstract |Full Text PDF

9.Reevaluating the Case of an Allegedly Absent Circumflex Artery: A Detailed Analysis of İnce et al.’s Report
Zhanwen Xu, Yu Zhang
PMID: 38619501  PMCID: PMC11059224  doi: 10.14744/AnatolJCardiol.2024.4327  Pages 258 - 259
Abstract |Full Text PDF

10.Reply to Letter to the Editor: “Reevaluating the Case of an Allegedly Absent Circumflex Artery: A Detailed Analysis of İnce et al.’s Report”
Orhan İnce, Kamil Gülşen, Sevil Tuğrul, İrfan Şahin, Ertuğrul Okuyan
PMID: 38619500  PMCID: PMC11059229  doi: 10.14744/AnatolJCardiol.2024.4313  Pages 260 - 262
Abstract |Full Text PDF

11.Interventricular Septal Dissection Secondary to Inferior Wall Myocardial Infarction
Vidiyala Pujitha, Niraj Nirmal Pandey, Sanjeev Kumar, Rakesh Yadav
PMID: 38372345  PMCID: PMC11059223  doi: 10.14744/AnatolJCardiol.2024.4242  Pages E17 - E18
Abstract |Full Text PDF

12.Lyme Carditis: Where Is the Site of the Atrioventricular Block?
Gamze Aktaş, Mustafa Yenerçağ, Ezgi Merve Çelik, İrem Ünal, Ahmet Korkmaz, Fırat Özcan, Serkan Çay, Özcan Özeke, Dursun Aras, Serkan Topaloğlu
PMID: 38430117  PMCID: PMC11059225  doi: 10.14744/AnatolJCardiol.2024.4266  Pages E19 - E21
Abstract |Full Text PDF

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