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Volume : 16 Issue : 9 Year : 2021
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The Anatolian Journal of Cardiology Relationship between the presence of left atrial thrombus in patients with mitral stenosis and platelet-to-lymphocyte ratio [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(9): 673-677 | DOI: 10.5152/AnatolJCardiol.2015.6485

Relationship between the presence of left atrial thrombus in patients with mitral stenosis and platelet-to-lymphocyte ratio

Erdal Belen1, Ender Özal2, Hamdi Püsüroğlu3
1Department of Cardiology, Okmeydanı Training and Research Hospital, İstanbul- Turkey
2Department of Cardiology, Pendik State Hospital, İstanbul- Turkey
3Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul- Turkey

Objective: Rheumatic carditis-induced mitral valve disease is associated with a chronic inflammatory process. The close relationship between inflammation and prothrombotic processes is known. Our goal was to examine the relationship between the presence of left atrial (LA) thrombus in patients with rheumatic mitral valve stenosis (RMVS) and platelet-to-lymphocyte ratio (PLR), which is an inflammatory marker.
Methods: This cross-sectional study included 351 consecutive patients diagnosed with RMVS upon presentation to the cardiology polyclinic. All patients were evaluated using transthoracic and transesophageal echocardiography and were divided into 2 groups: those with and without LA thrombus. In addition to echocardiographic and biochemical parameters, PLR was compared between the groups. Student’s t-test, Mann–Whitney U test, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were used for statistical analysis.
Results: No significant differences in terms of age, gender, body mass index, and comorbidities were found between the groups with and without LA thrombus. In the group with LA thrombus, higher red cell distribution width, mean platelet volume, and platelet count and lower lymphocyte count were detected. In addition, C-reactive protein levels were significantly higher in the LA thrombus group (4.7 vs. 2.7 mg/L, p<0.001). PLR was significantly higher in patients with thrombus than in those without (133±38 vs. 119±31, p=0.001). Higher PLR was identified as independently associated with the presence of LA thrombus (odds ratio: 1.03, 95% confidence interval: 1–1.06, p=0.016).
Conclusion: Higher PLR was detected in the LA thrombus group of patients with RMVS. (Anatol J Cardiol 2016; 16: 673-7)

Keywords: C-reactive protein, inflammation, platelet-to-lymphocyte ratio, rheumatic mitral valve stenosis, thrombosis

Erdal Belen, Ender Özal, Hamdi Püsüroğlu. Relationship between the presence of left atrial thrombus in patients with mitral stenosis and platelet-to-lymphocyte ratio. Anatol J Cardiol. 2016; 16(9): 673-677

Corresponding Author: Erdal Belen, Türkiye