2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara
3Başkent Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Ankara, Türkiye
4Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye
Abstract
Objective: This study was designed to compare the effects of simvastatin versus a combination of simvastatin with vitamin C or E on serum lipid profile, particularly, high density lipoprotein (HDL)-cholesterol (C) level, in patients with a low HDL-C level. Methods: Fifty-nine women and 49 men, who had a baseline HDL-C level equal to or lower than 40 mg/dl were randomized to one of the following study treatment groups: Group S (n=39) simvastatin 20 mg/day, Group S+C (n=33) simvastatin 20 mg/day + vitamin C 500 mg/day, and Group S+E (n=36) simvastatin 20 mg/day + vitamin E 400 IU/day. The groups’ lipid profiles were obtained at baseline, 3rd and 6th months. Results: Comparing with baseline values, total-C and low density cholesterol (LDL-C) values significantly reduced (p<0.001) and HDL-C values significantly increased (Group S-33.9 ± 3.9 mg/dl vs. 39.8 ± 6.9 mg/dl, Group S+C-34.2 ± 3.5 mg/dl vs. 38.1 ± 6.1 mg/dl, Group S+E-33.1 ± 3.6 mg/dl vs. 34.8 ± 5.9 mg/dl, p<0.001) on therapy within the groups; however, there were no significant differences among the groups with regards to these parameters. The HDL-C levels increased from baseline by 14.0 %, 11.7 % and 10.2% in Group S, S+C, and S+E, respectively (p>0.05). Conclusion: A combination of simvastatin with antioxidant vitamins does not offer any beneficial effect over simvastatin alone. Particularly vitamin E seems to blunt the simvastatin induced HDL-C increase.
2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara
3Başkent Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Ankara, Türkiye
4Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye