2Department of Biochemistry Faculty of Medicine Mersin University, Mersin, Turkey
3Department of Cardiology, Faculty of Medicine, İnönü University, Malatya-Turkey
4From Department of Cardiology Medical Faculty, Mersin University, Mersin, Turkey
5From Department of Biochemistry Medical Faculty, Mersin University, Mersin, Turkey
6Clinic of Cardiology, 70th Year Tarsus State Hospital, Mersin
Abstract
Objective: Short episodes of myocardial ischemia during coronary angioplasty may induce oxidative stress and increase lipid peroxida- tion. The aim of this study was to determine the effect of metoprolol on lipid peroxidation by measurements of malondialdehyde (MDA) and total antioxidant capacity (TRAP) in patients undergoing angioplasty. The relations between homocysteine level and lipid peroxida- tion were also studied. Methods: Forty-six patients (mean age 57 years, 37 males) undergoing elective angioplasty were enrolled. Metoprolol treatment was ini- tiated in 27 patients (group 1), meanwhile 19 patients could not take metoprolol due to diverse contraindications (group 2). Results: Following angioplasty, while venous MDA levels decreased in group 1 (0.188±0.021 vs. 0.159±0.020 nmol/ml, p=0.05), an increase was detected in group 2 (0.203±0.025 vs. 0.229±0.024 nmol/ml, p=0.045) as compared with baseline levels. In group 1, TRAP levels marked- ly increased after angioplasty in venous samples (1.201±0.036 vs. 1.478±0.044 mmol/L, p=0.0001). However, small increase was observed for TRAP in group 2 (1.274±0.043 vs. 1.363±0.053 mmol/L, p=0.05). There was no significant change in plasma homocysteine levels with angioplasty. There was no significant correlation between homocysteine, changes in MDA and TRAP levels either. Conclusion: Administration of metoprolol may cause a reduction in the oxidative stress and an increase in the antioxidant activity in patients undergoing elective angioplasty.