2Departments of Cardiology, Numune Education and Research Hospital, Ankara-Turkey
3Family Medicine, Numune Education and Research Hospital, Ankara-Turkey
4Department of Cardiology, Gazi Mustafa Kemal State Hospital, Ankara-Turkey
5Department of Cardiology, 29 Mayıs State Hospital, Ankara-Turkey
6Department of Cardiology, Erciş State Hospital, Van-Turkey
7Department of Cardiology, Faculty of Medicine, Gazi University, Ankara-Turkey
Abstract
Objective: Previous studies have suggested that there is a relationship between coronary artery disease (CAD) and parathyroid hormone (PTH) levels. Here, we aimed to evaluate the association between PTH levels and severity of CAD.
Methods: Patients were divided into two groups based on their serum PTH values. Patients with PTH levels ≤72 pg/mL were accepted as Group 1 (n=568) and >72 pg/mL as Group 2 (n=87). Gensini score system and >50% stenosis in any coronary artery with conventional coronary angiog- raphy were used to determine the extensiveness of CAD. This study was designed as a prospective and cross-sectional study.
Results: Baseline characteristics except for age, gender, and blood pressure were similar between groups. Mean serum PTH levels of the entire cohort was 43.4±29.5 pg/mL. Median Gensini score was 19.5 in Group 1 and 14.5 in Group 2 (p=0.75). On the other hand, PTH levels were weakly correlated with Gensini score (Spearman’s Rho=0.11, p=0.003). Additionally, we did not observe a statistically significant difference between PTH levels and the number of stenotic vessels (p=0.14). This study was designed as a prospective and cross-sectional study.
Conclusion: There is no association between serum PTH levels and extensiveness of CAD. (Anatol J Cardiol 2016; 16: 839-43)