Short-term effect of nebivolol on the left ventricular diastolic function

Demiralp, Ergün; Kardeşoğlu, Ejder; Çelik, Turgay; Sıtkı Cebeci, Bekir; Özmen, Namık; Işılak, Zafer; Eralp  Ulusoy, Rıfat; Dinçtürk, Mehmet

Original Investigation

Ergün Demiralp ¹ , Ejder Kardeşoğlu ² , Turgay Çelik ³ , Bekir Sıtkı Cebeci ² , Namık Özmen ² , Zafer Işılak ¹ , Rıfat Eralp Ulusoy ⁷ , Mehmet Dinçtürk ⁸

¹Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
²Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
³Department of Cardiology School of Medicine, Gülhane Military Medical Academy, Etlik, Ankara
⁴Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
⁵Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
⁶Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
⁷Cardiology Section, GATA Haydarpaşa Teaching Hospital, Üsküdar, İstanbul, Turkey
⁸GATA Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul, Türkiye

Anatol J Cardiol 2004; 4(4): 323-326 PubMed ID: 15590361

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Abstract

Objective: To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period. Methods: Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value. Results: The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period. Conclusion: We found that nebivolol improved left ventricle diastolic function in patients with hypertension in the early term.

Keywords: Nebivolol, hypertension, left ventricle diastolic functions

Nebivololün sol ventrikül diyastolik fonksiyonları üzerine erken dönem etkisi

Ergün Demiralp¹ , Ejder Kardeşoğlu² , Turgay Çelik³ , Bekir Sıtkı Cebeci² , Namık Özmen² , Zafer Işılak¹ , Rıfat Eralp Ulusoy⁷ , Mehmet Dinçtürk⁸

¹Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
²Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
³Department of Cardiology School of Medicine, Gülhane Military Medical Academy, Etlik, Ankara
⁴Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
⁵Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
⁶Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
⁷Cardiology Section, GATA Haydarpaşa Teaching Hospital, Üsküdar, İstanbul, Turkey
⁸GATA Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul, Türkiye

The Anatolian Journal of Cardiology 2004; 4(4): 323-326 PMID: 15590361

Anahtar Kelimeler: Nebivolol, hipertansiyon, sol ventrikül diyastolik fonksiyonları