2Clinics of Radiology, Ümraniye Education and Research Hospital, İstanbul-Turkey
3Clinics of Internal Medicine, Haydarpaşa Numune Education and Research Hospital, İstanbul-Turkey
4Department of Internal Medicine Haydarpasa Numune Training and Research Hospital, İstanbul
5Cardiology Department, Siyami Ersek Thoracic and Cardiovascular Surgery Center, İstanbul, Turkey
6Clinic of Nucleer Medicine, Dr.Siyami Ersek Thoracic Cardiovascular Surgery Education
7Clinics of Endocrine and Metabolic Disease, Şişli Etfal Education and Research Hospital, İstanbul-Turkey
Abstract
Objective: This study aims to investigate long-term effects of iodinated radiographic contrast media used for coronary angiography (CAG) on the thyroid function in euthyroid patients. Methods: In a prospective observational cohort study, nonionic iodinated contrast material was electively used in 101 patients for coronary angiography. The patients were recruited without age restrictions and, at baseline, all had normal levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH). The morphology of the thyroid was evaluated by thyroid ultrasonography (USG). Four and eight weeks after CAG, serum TSH, FT3 and FT4 levels were assessed. Results: Compared to a mean baseline level of 1.49 (25%-75%, range 13-2.21), follow-up TSH levels decreased significantly to 1.45 (25%-75%, range 1.98-0.92, p=0.017) and 1.40 (25%-75%, range 1.89-0.87, p=0.003) at 4 weeks and 8 weeks, respectively (p=0.008). No significant diffe-rence was observed in TSH levels between the 4th and 8th weeks (p=0.833). Conclusion: Iodinated radiographic contrast agents may cause subclinical hyperthyroidism in euthyroid patients undergoing CAG.