Letter to the Editor Reply

Reply to Letter to the Editor: “Can Differences in Non-Vitamin K Antagonist Oral Anticoagulant Preferences Result in Varying Clinical Outcomes in Patients with Atrial Fibrillation?”

Serkan Ünlü ¹ , Servet Altay ² , Ömer Gedikli ³ , Özge Özden ⁴ , Uğur Canpolat ⁵ , Lütfü Aşkın ⁶ , Çağrı Yayla ⁷ , Ahmet Yanık ⁸ , Hüseyin Altuğ Çakmak ⁹ , Ümit Yaşar Sinan ¹⁰ , Feyzullah Beşli ¹¹ , Mahmut Şahin ³ , Seçkin Pehlivanoğlu ¹²

¹Department of Cardiology, Faculty of Medicine, Gazi University, Ankara, Türkiye
²Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Türkiye
³Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye
⁴Department of Cardiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye
⁵Department of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye
⁶Department of Cardiology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye
⁷Department of Cardiology, Yüksek İhtisas Training and Research Hospital, Ankara, Türkiye
⁸Department of Cardiology, Samsun Training and Research Hospital, Samsun, Türkiye
⁹Department of Cardiology, Mustafa Kemal Paşa State Hospital, Bursa, Türkiye
¹⁰Institute of Cardiology, Faculty of Medicine, İstanbul University, İstanbul, Türkiye
¹¹Department of Cardiology, Faculty of Medicine, Harran University, Şanlıurfa, Türkiye
¹²Department of Cardiology, Faculty of Medicine, Başkent University, İstanbul, Türkiye

Anatol J Cardiol 2024; 28(1): 70-70 PubMed ID: 38167800 PMCID: 10796243 DOI: 10.14744/AnatolJCardiol.2023.4097

CONTENT

To the Editor,

We extend our gratitude to the authors for their thorough review and reiterated emphasis on the pivotal aspects of the presented findings of our study¹ in their correspondence titled “Can Differences in Non-Vitamin K Antagonist Oral Anticoagulant Preferences Result in Varying Clinical Outcomes in Patients with Atrial Fibrillation?”²

Since our article presents real-life data, it was not possible to evaluate the appropriate or inappropriate doses of the agents used. Our investigation centered on assessing medications prescribed by cardiologists within their customary practice, deeming these dosages appropriate for their respective patients.

In routine clinical practice, meticulous evaluation by cardiologists to determine optimal patient assessment and dosage allocation holds significant importance. This decision-making process necessitates comprehensive awareness of patient-specific risk factors alongside a profound grasp of both pharmacodynamic and pharmacokinetic characteristics associated with the prescribed medication. Our investigation exclusively encompassed patients under the care of cardiologists for non-valvular atrial fibrillation, a subset acknowledged for its extensive familiarity and predominant utilization of this class of medications. The possibility of inadequacies in the initiation of appropriate drug dosages remains relevant across the spectrum of all non-vitamin K antagonist oral anticoagulants groups examined in our study. Such occurrences, universally applicable to all categories, may stem from deficiencies in knowledge pertaining to drug usage or apprehensions regarding potential drug-related effects. This scenario could potentially be applicable to any drug category examined within our study. If this situation was indeed present for a specific drug and dosage and impacted the results, as criticized by the authors, it would also indicate a high incidence of incorrect dosage selection for the specific drug in everyday clinical practice which still would potentially lead to experiencing adverse cardiac endpoints. The significance of real-world data studies lies in their absence of an overarching regulatory mechanism, thereby offering a portrayal of challenges patients might encounter in their everyday lives. These studies serve as a pragmatic reflection of clinical scenarios and contribute substantial insights into patient experiences beyond controlled settings.

References

1. Ünlü S, Altay S, Gedikli Ö. Real-world data on the incidence of stroke, myocardial infarction, and mortality among nonvalvular atrial fibrillation patients in Türkiye: new oral anticoagulants-TURKey study. Anatol J Cardiol. 2024;():19-28. https://doi.org/10.14744/AnatolJCardiol.2023.3389
2. Özlek B. Can differences in NOAC preferences result in varying clinical outcomes in patients with atrial fibrillation?. Anatol J Cardiol. 2024;():68-69.