Objectives: Early diagnosis and treatment of coronary artery disease is gaining more importance because of its increasing incidence. The calculation of coronary risk score is one of the most important approaches. The aim of the study is to find out the relation between coro- nary risk score and vessel distribution of the coronary heart disease. Methods: The study included 49 patients (mean age= 63±8 years; 36 males) whose coronary disease was proven by coronary angiogra- phy. The severity of the disease is established according to the number of the vessels with >50% stenosis. Results: According to the results; age (p=0.548), gender (p=0.116), uric acid (p=0.091), and smoking (p=0.718) are not effective on diseased vessel distribution. Similarly, total coronary risk score and vessel involvement was not correlated (p=0.115). The ten year coronary risk and vessel involvement was not in good correlation, too (p=0.523). Low-density lipoprotein (LDL)-cholesterol levels were lower in patients with multiple vessel disease but the statistical significance was borderline (p=0.051). High-density lipoprotein (HDL)-cholesterol levels were lower in multiple vessel disease (p=0.004). Both LDL-cholesterol and HDL-cholesterol scores were decreasing with increased num- ber of involved vessels (p=0.035, p=0.001). Multivariate analysis revealed that blood pressure score, and HDL cholesterol score were directly related and LDL-score were inversely related to the number of the involved vessels. The height and vessel involvement was also in good correlation (p=0.024). Conclusion: The LDL-cholesterol, HDL-cholesterol, diastolic blood pressure and height are affective on the number of the involved ves- sels. The total coronary risk scores are not correlated with the severity and distribution of the disease.