Association Between Angiotensin Converting Enzyme Gene Polymorphism and Coronary Artery Disease in Individuals of the South-Eastern Anatolian Population

Nacak, Muradiye; Davutoğlu, Vedat; Soydinç, Serdar; Dinçkal, Hakan; Türkmen, Serdar; Erbağcı, Binnur; Akçay, Murat; Aynacıoğlu, Şükrü

Original Investigation

Muradiye Nacak ¹ , Vedat Davutoğlu ² , Serdar Soydinç ³ , Hakan Dinçkal ³ , Serdar Türkmen ⁴ , Binnur Erbağcı ⁵ , Murat Akçay ⁶ , Şükrü Aynacıoğlu ⁵

¹University of Gaziantep, Department of Cardiology, Gaziantep
²Gaziantep Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Gaziantep, Türkiye
³University of Gaziantep, Department of Pharmacology, Gaziantep
⁴University of Gaziantep, Department of Biochemistry, Gaziantep Adıyaman State Hospital, Adıyaman
⁵Pharmacogenetics Laboratory, Epidauros Biotechnology AG, Bernried-Germany
⁶Cardiology Clinic, Atatürk Education and Research Hospital, Ankara, Turkey

Anatol J Cardiol 2004; 4(1): 45-51 PubMed ID: 15033618

Full Text PDF

Abstract

Objective: The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene has been proposed as a genetic marker of the risk of coronary artery disease (CAD). In this study we aimed to determine the relevance of ACE gene polymorphism for coronary artery disease in the South-Eastern Anatolian population. Methods: Angiotensin converting enzyme genotypes were determined in 133 CAD patients who underwent coronary angiography. Severity of CAD was subgrouped according to the number of stenotic vessels on coronary angiography. The control group was selected from 154 healthy volunteers. Angiotensin converting enzyme genotypes were determined by agarose gel sizing after polymerase chain reaction (PCR) amplification. Results: Frequency of ACE DD genotype did not differ between patients with CAD and control subjects. However the ACE II genotype in CAD group was significantly less frequent than in control group (p=0.02). The relative risks were 0.9 (95% CI=0.56-1.43) for the DD genotypes, and 2.2 (95% CI=1.09 – 4.11) for the II genotype. In the 2-vessel CAD subgroups, the II genotypes were significantly different from control group. Conclusion: Our study did not confirm the possibility that the ACE DD genotypes may be associated with predisposition to CAD in this certain population but there is a relationship between the least frequencies of the II genotype and CAD. The II genotype seems to be an independent protective factor for CAD in the South-Eastern Anatolian population.

Keywords: ACE gene polymorphism, coronary artery disease, South-Eastern Anatolia

Güneydoğu Anadolu Populasyonunda Anjiyotensin Konverting Enzim Gen Polimorfizmi ve Koroner Arter Hastalığı İlişkisi

Muradiye Nacak¹ , Vedat Davutoğlu² , Serdar Soydinç³ , Hakan Dinçkal³ , Serdar Türkmen⁴ , Binnur Erbağcı⁵ , Murat Akçay⁶ , Şükrü Aynacıoğlu⁵

¹University of Gaziantep, Department of Cardiology, Gaziantep
²Gaziantep Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Gaziantep, Türkiye
³University of Gaziantep, Department of Pharmacology, Gaziantep
⁴University of Gaziantep, Department of Biochemistry, Gaziantep Adıyaman State Hospital, Adıyaman
⁵Pharmacogenetics Laboratory, Epidauros Biotechnology AG, Bernried-Germany
⁶Cardiology Clinic, Atatürk Education and Research Hospital, Ankara, Turkey

The Anatolian Journal of Cardiology 2004; 4(1): 45-51 PMID: 15033618

Anahtar Kelimeler: ACE gen polimorfizmi, koroner arter hastalığı, Güneydoğu Anadolu