Original Article Clinical and Angiographic Predictors of Creatine Kinase Enzyme Elevation After Successful Coronary Stent Implantation: Effects on Subsequent Target Vessel Revascularization Erhan Babalık 1, Kadriye Orta 1, Tevfik Gürmen 1, Murat Gülbaran 1, Servet Öztürk 1, Barış Ökçün 1 1 İstanbul Üniversitesi Kardiyoloji Enstitüsü, Kardiyoloji Anabilim Dalı, İstanbul Anatol J Cardiol 2003; 3: 107-112 This article was viewed 121 times, downloaded 0 times Key Words: Stent, koroner, kreatin kinaz, revaskülarizasyon Full Text (PDF) Related Articles Send a comment Share Abstract Objective: The aims of the present study are to evaluate clinical, angiographic, and procedural determinants of creatine kinase (CK) elevation following successful coronary stent implantation, and to assess the relationship between postprocedural CK release and subsequent target vessel revascularization. Methods: Study population was composed of 400 consecutive patients who underwent successful coronary stent implantation. Forty-six patients (11.5%) had CK enzyme levels >2 times the upper limit of normal. This group was compared to 100 patients with no CK release after stenting. Results: Baseline, angiographic and procedural characteristics did not differ between patients with and without postprocedural CK elevation. The significant predictors of CK elevation by multiple logistic regression analysis are unstable angina (p<0.001, OR=5.62 with 95% CI of 2.35-13.45), multiple stenting (p=0.04, OR=2.55 with 95% CI of1.02-6.40) and side branch occlusion (p=0.03,OR=12.20 with 95% CI of 1.22-121.71). By multivariate analysis, postprocedural CK release was found to be a significant determinant of subsequent target vessel revascularization (p=0.032,OR=3.84 with 95% CI of 1.12-13.18). Conclusion: Our results indicate that side branch occlusion, implantation of > 1 stents per lesion and coronary stenting in unstable angina pectoris are strong predictors of postprocedural CK release. There is a significant relationship between postprocedural CK elevation and subsequent target vessel revascularization.