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The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(4): 318-322

The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels

Bahar Pirat1, Mehmet E. Korkmaz2, Serpil Eroğlu3, Egemen Tayfun2, Aylin Yıldırır1, Melek Uluçam4, Bülent Özin2
1Department of Cardiology, Faculty of Medicine, Başkent University, Ankara, Turkey
2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara
3Başkent Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Ankara, Türkiye
4Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye

Objective: This study was designed to compare the effects of simvastatin versus a combination of simvastatin with vitamin C or E on serum lipid profile, particularly, high density lipoprotein (HDL)-cholesterol (C) level, in patients with a low HDL-C level. Methods: Fifty-nine women and 49 men, who had a baseline HDL-C level equal to or lower than 40 mg/dl were randomized to one of the following study treatment groups: Group S (n=39) simvastatin 20 mg/day, Group S+C (n=33) simvastatin 20 mg/day + vitamin C 500 mg/day, and Group S+E (n=36) simvastatin 20 mg/day + vitamin E 400 IU/day. The groups’ lipid profiles were obtained at baseline, 3rd and 6th months. Results: Comparing with baseline values, total-C and low density cholesterol (LDL-C) values significantly reduced (p<0.001) and HDL-C values significantly increased (Group S-33.9 ± 3.9 mg/dl vs. 39.8 ± 6.9 mg/dl, Group S+C-34.2 ± 3.5 mg/dl vs. 38.1 ± 6.1 mg/dl, Group S+E-33.1 ± 3.6 mg/dl vs. 34.8 ± 5.9 mg/dl, p<0.001) on therapy within the groups; however, there were no significant differences among the groups with regards to these parameters. The HDL-C levels increased from baseline by 14.0 %, 11.7 % and 10.2% in Group S, S+C, and S+E, respectively (p>0.05). Conclusion: A combination of simvastatin with antioxidant vitamins does not offer any beneficial effect over simvastatin alone. Particularly vitamin E seems to blunt the simvastatin induced HDL-C increase.

Keywords: Simvastatin, antioxidant vitamins, HDL-cholesterol

HDL kolesterol düzeyi düşük olan bireylerde statin tedavisine farklı antioksidan vitaminlerin eklenmesinin serum lipid profili üzerine etkisi

Bahar Pirat1, Mehmet E. Korkmaz2, Serpil Eroğlu3, Egemen Tayfun2, Aylin Yıldırır1, Melek Uluçam4, Bülent Özin2
1Department of Cardiology, Faculty of Medicine, Başkent University, Ankara, Turkey
2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara
3Başkent Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Ankara, Türkiye
4Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye


Bahar Pirat, Mehmet E. Korkmaz, Serpil Eroğlu, Egemen Tayfun, Aylin Yıldırır, Melek Uluçam, Bülent Özin. The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels. Anatol J Cardiol. 2004; 4(4): 318-322
Manuscript Language: English