ISSN 2149-2263 | E-ISSN 2149-2271
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The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(12): 712-719 | DOI: 10.14744/AnatolJCardiol.2023.3381

The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome

İbrahim Etem Çelik1, Selçuk Öztürk2, Mikail Yarlıoğlu1, Ozan Barutçu1, Onur Akgün3, Mustafa Duran1, Şükrü Yorulmaz4, Sani Namık Murat1
1Department of Cardiology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye
2Department of Cardiology, Kırıkkale Yüksek İhtisas Hospital, Kırıkkale, Türkiye
3Department of Cardiology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Türkiye
4Department of Emergency Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye

Background: The atherogenic index of plasma (AIP) is a biomarker of plasma atherogenicity. Elevated AIP is linked with adverse cardiac events. We sought to examine the association of admission AIP and no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patient population treated with percutaneous coronary intervention (PCI).

Methods: Eight hundred eight-four ACS patients were included to statistical tests retrospectively and classified according to the occurrence of NRP: NRP (−) (n = 662) and NRP (+) (n = 186). AIP levels were calculated through the formula log10 (triglyceride-to-high-den sity lipoprotein cholesterol ratio).

Results: AIP levels were higher in NRP (+) patients compared to NRP (−) group patients. The receiver operating characteristic (ROC) curve analysis for AIP to predict NRP yielded an area under the ROC curve value 0.643 [95% confidence interval (CI): 0.596-0.690, P <.001]. AIP was associated with NRP in univariate logistic regression analysis [Odds Ratio (OR): 2.46; P =.001; CI: 1.44 (lower limit)-4.21 (upper limit)]. However, AIP did not emerge as a significant prognostic factor of NRP in multiple logistic regression analysis [OR: 2.11; P =.422; CI: 0.34 (lower limit)-13.11 (upper limit)]. On the other hand, peak troponin T (log10) was an independent prognostic factor for NRP [OR: 0.13; P <.001; CI: 0.10 (lower limit)-0.37 (upper limit)] occurrence.

Conclusion: The AIP level on admission is not a statistically significant prognostic factor of NRP. However, peak troponin T (log10) is an independent prognostic parameter of NRP.

Keywords: Acute coronary syndrome, atherogenic index of plasma, atherosclerosis, no-reflow phenomenon, troponin

İbrahim Etem Çelik, Selçuk Öztürk, Mikail Yarlıoğlu, Ozan Barutçu, Onur Akgün, Mustafa Duran, Şükrü Yorulmaz, Sani Namık Murat. The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome. Anatol J Cardiol. 2023; 27(12): 712-719

Corresponding Author: Selçuk Öztürk, Türkiye
Manuscript Language: English


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