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Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(12): 940-946 | DOI: 10.14744/AnatolJCardiol.2016.6876

Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study

Ali Buturak1, Aleks Değirmencioğlu1, Fatih Bayrak1, Tuncay Kırış2, Hüseyin Karakurt3, Ali Rıza Demir3, Özgür Sürgit3, Mehmet Ertürk3
1Department of Cardiology, Faculty of Medicine, Acıbadem University; İstanbul-Turkey
2Department of Cardiology, Katip Çelebi University Atatürk Research Hospital; İzmir-Turkey
3Department of Cardiology, Mehmet Akif Ersoy Cardiovascular Surgery Education and Research Hospital; İstanbul-Turkey

Objective: Bioactive roles of adipokines in coronary atherosclerosis and acute coronary syndromes have been demonstrated previously. Ho-
wever, there is a lack of data regarding the relationship between serum adipokines and periprocedural myocardial injury (PMI) following elective percutaneous coronary intervention (PCI). Therefore, we aimed to investigate the association between serum adipokines and PMI related to elective PCI.
Methods: In total, 153 consecutive patients (aged 60.6±8.2 years, 98 men) with stable angina pectoris undergoing elective PCI were enrolled in this observational cross-sectional study. Serum resistin, leptin, adiponectin, and high-sensitive Troponin T (hscTnT) levels were measured immediately before PCI and after 12-h PCI. The no-injury, PMI, and type 4a myocardial infarction (type 4a MI) groups were defined as groups consisting patients with post-procedural hscTnT concentrations <14 ng/L, between 14–70 ng/L, and >70 ng/L, respectively.
Results: Serum hscTnT, resistin, and leptin concentrations significantly (p<0.001) increased while serum adiponectin levels decreased (p<0.001) after 12-h elective PCI. However, no correlation was found between post-procedural hscTnT concentrations and resistin, leptin, and adiponectin levels. The no-injury group consisted of 65 patients (42.4%), whereas PMI and type 4a MI were observed in 70 (45.8%) and 18 (11.8%) patients, respectively. The average pre-procedural and post-procedural resistin, leptin, and adiponectin levels did not show any significant difference in the no-injury, PMI, and type 4a MI groups.
Conclusion: There is no correlation between serum adipokine levels and post-procedural troponin elevations reflecting PMI or type 4a MI. However, serum resistin and leptin levels increase, whereas adiponectin levels decrease significantly after elective PCI.
(Anatol J Cardiol 2016; 16: 940-6)

Keywords: resistin, leptin, adiponectin, coronary

Ali Buturak, Aleks Değirmencioğlu, Fatih Bayrak, Tuncay Kırış, Hüseyin Karakurt, Ali Rıza Demir, Özgür Sürgit, Mehmet Ertürk. Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study. Anatol J Cardiol. 2016; 16(12): 940-946

Corresponding Author: Ali Buturak, Türkiye