ISSN 2149-2263 | E-ISSN 2149-2271
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Relationship Between Urinary Angiotensinogen and Mortality in Patients with Heart Failure with Reduced Ejection Fraction [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-31040 | DOI: 10.14744/AnatolJCardiol.2023.2719

Relationship Between Urinary Angiotensinogen and Mortality in Patients with Heart Failure with Reduced Ejection Fraction

Özcan Örsçelik1, Emrah Yeşil1, Hakan Uyar2, Ali Orçun Sürmeli3, Buğra Özkan1, Mehmet Burak Yavuz Çimen4
1Department of Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey
2Department of Cardiology, Mersin City Training and Research Hospital, Mersin, Turkey
3Department of Cardiology, Tarsus State Hospital, Mersin, Turkey
4Department of Medical Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey

Background: Activation of the reninangi otens in-aldosterone system has an important role in the pathophysiology of heart failure with reduced ejection fraction. While the effects of systemic reninangi otens in-aldosterone system activation on heart failure with reduced ejection fraction are well known, the impact of the local reninangi otens in-aldosterone system on heart failure with reduced ejection fraction is not fully understood because of limited clinical research. This study aimed to investigate the effect of urinary angiotensinogen level, an accepted indicator of local reninangi otens in-aldosterone system activation, on all-cause mortality in patients with heart failure with reduced ejection fraction.
Methods: This retrospective, single-center study included 60 patients with baseline urinary angiotensinogen data and survival/mortality data at 4 years. Urinary angiotensinogen values were standardized to the urinary creatinine value measured from the same urine sample. The median urinary angio tensi nogen /urin ary creatinine value among all patients (114 μg/g) was used as a cutoff to divide the patients into 2 groups. Mortality data were obtained from the national registry systems or by telephone.

Results: Comparison of all-cause mortality in the 2 groups showed that 22 deaths (71%) occurred in the group with a urinary angio tensinogen/urinary creatinine ratio above the median and 10 deaths (35.5%) occurred in the group of patients with urinary angio tensinogen/urinary creatinine equal to or below the median value (P =.005).

Conclusion: Our study suggests that urinary angiotensinogen can be used as a new biomarker in the prognosis and follow-up of heart failure patients.

Keywords: Heart failure with reduced ejection fraction, local reninangi otens in-aldosterone system, urinary angiotensinogen



Corresponding Author: Emrah Yeşil, Türkiye
Manuscript Language: English


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