ISSN 2149-2263 | E-ISSN 2149-2271
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Turkish Real Life Atrial Fibrillation in Clinical Practice: TRAFFIC Study [Anatol J Cardiol]
Anatol J Cardiol. 2024; 28(2): 87-93 | DOI: 10.14744/AnatolJCardiol.2023.3616

Turkish Real Life Atrial Fibrillation in Clinical Practice: TRAFFIC Study

Can Yücel Karabay1, Hakan Taşolar2, Ayşegül Ülgen Kunak3, Murat Çap4, Mehmet Ali  Astarcıoğlu5, Taner Şen5, Mehmet Kaplan6, Muharrem Said Coşgun7, Fahriye Vatansever Ağca8, Uğur Arslan9, Gönül Açıksarı10, Fahri Er11, Kadir Uğur  Mert12, Öner Özdoğan13, Serhat Çalışkan14, Ercan Akşit15, Ahmet Seyda  Yılmaz16, Emrah Aksakal17, Zeki Şimşek18, Süleyman Çağan  Efe18, Gülşah Aktüre19, Ferit Böyük20, Özcan Başaran21, Mehmet Ballı22, Ahmet Oğuz  Aslan23, Gamze Babur Güler24, Ulaankhuu Batgerel25, Flora Özkalaycı26, Bedri Caner  Kaya27, Batur Gönenç  Kanar28, Muammer Karakayalı29, Emrah Erdoğan30, Gürkan İş31, Sedat Kalkan32, Sinan Demirel32, Uğur Aksu33, Ümit Güray34, Hasan Aydın  Baş35, Murat Gök36, Mehmet Fatih  Yılmaz1, Barış Şimşek1, Zeynep Kolak1, Melih Öz1, Utku Uluköksal1, Hüseyin Emre  Kuloğlu2, Gizem Çabuk13, Fatma Köksal22, Ahmet Cem Nizam28, Rabia Çoldur30, Faysal Şaylık37, İbrahim Halil Tanboğa38
1Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Türkiye
2Department of Cardiology, İnönü University Faculty of Medicine, Malatya, Türkiye
3Department of Cardiology, Medstar Topçular Hospital, Antalya, Türkiye
4Department of Cardiology, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakır, Türkiye
5Department of Cardiology, University of Health Sciences, Evliya Çelebi Training and Research Hospital, Kütahya, Türkiye
6Department of Cardiology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye
7Department of Cardiology, Erzincan Binali Yıldırım University Faculty of Medicine, Erzincan, Türkiye
8Department of Cardiology, Bursa High Specialization Training and Research Hospital, Bursa, Türkiye
9Department of Cardiology, Samsun Training and Research Hospital, Samsun, Türkiye
10Department of Cardiology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Türkiye
11Department of Cardiology, Ağrı Training and Research Hospital, Ağrı, Türkiye
12Department of Cardiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Türkiye
13Department of Cardiology, İzmir Tepecik Training and Research Hospital, İzmir, Türkiye
14Department of Cardiology, İstanbul Bahçelievler Public Hospital, İstanbul, Türkiye
15Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Türkiye
16Department of Cardiology, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye
17Department of Cardiology, Erzurum Regional Training and Research Hospital, Erzurum, Türkiye
18Department of Cardiology, Kartal Koşuyolu High Specialization Training and Research Hospital, İstanbul, Türkiye
19Department of Cardiology, Düzce University Training and Research Hospital, Düzce, Türkiye
20Department of Cardiology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye
21Department of Cardiology, Muğla Sıtkı Kocaman University Faculty of Medicine, Muğla, Türkiye
22Department of Cardiology, Mersin City Training and Research Hospital, Mersin, Türkiye
23Department of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Türkiye
24Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Türkiye
25Department of Cardiology, Kadıköy Acıbadem Hospital, İstanbul, Türkiye
26Department of Cardiology, Hisar Hospital Intercontinental, İstanbul, Türkiye
27Department of Cardiology, Şanlıurfa Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, Türkiye
28Department of Cardiology, Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye
29Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Türkiye
30Department of Cardiology, Van Yüzüncü Yıl University Faculty of Medicine, Van, Türkiye
31Department of Cardiology, Lösante Children’s and Adult Hospital, Ankara, Türkiye
32Department of Cardiology, Pendik State Hospital, İstanbul, Türkiye
33Department of Cardiology, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Türkiye
34Department of Cardiology, Ankara Bilkent City Hospital, Ankara, Türkiye
35Department of Cardiology, Isparta City Hospital, Isparta, Türkiye
36Department of Cardiology, Trakya University Faculty of Medicine, Edirne, Türkiye
37Department of Cardiology, Van Training and Research Hospital, Van, Türkiye
38Department of Biostatistics, Nişantaşı University Medical School, İstanbul, Türkiye

Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and is associated with an increased risk of thromboembolism, ischemic stroke, impaired quality of life, and mortality. The latest research that shows the prevalence and incidence of AF patients in Türkiye was the Turkish Adults’ Heart Disease and Risk Factors study, which included 3,450 patients and collected data until 2006/07.The Turkish Real Life Atrial Fibrillation in Clinical Practice (TRAFFIC) study is planned to present current prevalence data, reveal the reflection of new treatment and risk approaches in our country, and develop new prediction models in terms of outcomes.

Methods: The TRAFFIC study is a national, prospective, multicenter, observational registry. The study aims to collect data from at least 1900 patients diagnosed with atrial fibrillation, with the participation of 40 centers from Türkiye. The following data will be collected from patients: baseline demographic characteristics, medical history, vital signs, symptoms of AF, ECG and echocardiographic findings, CHADS2-VASC2 and HAS-BLED (1-year risk of major bleeding) risk scores, interventional treatments, antithrombotic and antiarrhythmic medications, or other medications used by the patients. For patients who use warfarin, international normalized ratio levels will be monitored. Follow-up data will be collected at 6, 12, 18, and 24 months. Primary endpoints are defined as systemic embolism or major safety endpoints (major bleeding, clinically relevant nonmajor bleeding, and minor bleeding as defined by the International Society on Thrombosis and Hemostasis). The main secondary endpoints include major adverse cardiovascular events (systemic embolism, myocardial infarction, and cardiovascular death), all-cause mortality, and hospitalizations due to all causes or specific reasons.

Results: The results of the 12-month follow-up of the study are planned to be shared by the end of 2023.

Conclusion: The TRAFFIC study will reveal the prevalence and incidence, demographic characteristics, and risk profiles of AF patients in Türkiye. Additionally, it will provide insights into how current treatments are reflected in this population. Furthermore, risk prediction modeling and risk scoring can be conducted for patients with AF.

Keywords: Arrhythmias, atrial fibrillation/flutter, atrial fibrillation, bleeding, catheter ablation

Can Yücel Karabay, Hakan Taşolar, Ayşegül Ülgen Kunak, Murat Çap, Mehmet Ali  Astarcıoğlu, Taner Şen, Mehmet Kaplan, Muharrem Said Coşgun, Fahriye Vatansever Ağca, Uğur Arslan, Gönül Açıksarı, Fahri Er, Kadir Uğur  Mert, Öner Özdoğan, Serhat Çalışkan, Ercan Akşit, Ahmet Seyda  Yılmaz, Emrah Aksakal, Zeki Şimşek, Süleyman Çağan  Efe, Gülşah Aktüre, Ferit Böyük, Özcan Başaran, Mehmet Ballı, Ahmet Oğuz  Aslan, Gamze Babur Güler, Ulaankhuu Batgerel, Flora Özkalaycı, Bedri Caner  Kaya, Batur Gönenç  Kanar, Muammer Karakayalı, Emrah Erdoğan, Gürkan İş, Sedat Kalkan, Sinan Demirel, Uğur Aksu, Ümit Güray, Hasan Aydın  Baş, Murat Gök, Mehmet Fatih  Yılmaz, Barış Şimşek, Zeynep Kolak, Melih Öz, Utku Uluköksal, Hüseyin Emre  Kuloğlu, Gizem Çabuk, Fatma Köksal, Ahmet Cem Nizam, Rabia Çoldur, Faysal Şaylık, İbrahim Halil Tanboğa. Turkish Real Life Atrial Fibrillation in Clinical Practice: TRAFFIC Study. Anatol J Cardiol. 2024; 28(2): 87-93

Corresponding Author: Can Yücel Karabay
Manuscript Language: English


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