ISSN 2149-2263 | E-ISSN 2149-2271
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Comparing the Diagnostic Performance of HFA-PEFF and H2FPEF Scoring Systems in Heart Failure with Preserved Ejection Fraction Patients: Insights from the APOLLON Registry [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(9): 539-548 | DOI: 10.14744/AnatolJCardiol.2023.3345

Comparing the Diagnostic Performance of HFA-PEFF and H2FPEF Scoring Systems in Heart Failure with Preserved Ejection Fraction Patients: Insights from the APOLLON Registry

Gurbet Özge Mert1, Bülent Özlek2, Eda Özlek2, Hicaz Zencirkiran Ağuş3, Mehmet Tekinalp4, Serkan Kahraman3, Cem Çil2, Oğuzhan Çelik2, Özcan Başaran2, Volkan Doğan2, Bedri Caner Kaya5, İbrahim Rencüzoğulları6, Altuğ Ösken7, Lütfü Bekar8, Mustafa Ozan Çakır9, Yunus Çelik10, Kadriye Memiç Sancar3, Samet Sevinç3, Murat Biteker2, Kadir Uğur Mert1
1Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Türkiye
2Department of Cardiology, Muğla Sıtkı Koçman University Training and Research Hospital, Muğla, Türkiye
3Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Türkiye
4Department of Cardiology, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş, Türkiye
5Department of Cardiology, Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, Türkiye
6Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Türkiye
7Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Türkiye
8Department of Cardiology, Hitit University Çorum Erol Olçok Training and Research Hospital, Çorum, Türkiye
9Department of Cardiology, Faculty of Medicine, Bülent Ecevit Universiy, Zonguldak, Türkiye
10Department of Cardiology, Kırıkkale Yüksek İhtisas Hospital, Kırıkkale, Türkiye

Background: Heart failure with preserved ejection fraction is a complex and heterogeneous clinical syndrome, poses significant diagnostic challenges. The HFA-PEFF [Heart Failure Association of ESC diagnostic algorithm, P (Pretest Assessment), E  (Echocardiographic and Natriuretic Peptide score), F1 (Functional testing in Case of Uncertainty), F2 (Final Aetiology)] and H2FPEF [Heavy (BMI>30 kg/m2), Hypertensive (use of ≥2 antihypertensive medications), atrial Fibrillation (paroxysmal or persistent), Pulmonary hypertension (Doppler Echocardiographic estimated Pulmonary Artery Systolic Pressure >35 mm Hg), Elderly (age >60 years), Filling pressure (Doppler Echocardiographic E/e’ >9)] scoring systems were developed to aid in diagnosing heart failure with preserved ejection fraction. This study aimed to assess the concordance and clinical accuracy of these scoring systems in the “A comPrehensive, ObservationaL registry of heart faiLure with mildly reduced and preserved ejection fractiON” cohort.

Methods: A comPrehensive, ObservationaL registry of heart faiLure with mildly reduced and preserved ejection fractiON study was conducted as a multicenter, cross-sectional, and observational study; to evaluate a group of Heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction patients who were seen by cardiologists in 13 participating centers across 12 cities in Türkiye.

Results: The study enrolled 819 patients with heart failure with preserved ejection fraction, with high probability heart failure with preserved ejection fraction rates of 40% and 26% for HFA-PEFF and H2FPEF scorings, respectively. The concordance between the 2 scoring systems was found to be low (Kendall’s taub correlation coefficient of 0.242, P < .001). The diagnostic performance of both scoring systems was evaluated, revealing differences in their approach and ability to accurately identify heart failure with preserved ejection fraction patients.

Conclusion: The low concordance between the HFA-PEFF and H2FPEF scoring systems underscores the ongoing challenge of accurately diagnosing and managing patients with heart failure with preserved ejection fraction. Clinicians should be aware of the strengths and limitations of each scoring system and use them in conjunction with other clinical and laboratory findings to arrive at an accurate diagnosis. Future research should focus on identifying additional diagnostic factors, developing more accurate and comprehensive diagnostic algorithms, and investigating alternative methods of diagnosis or stratification of patients based on different clinical characteristics.

Keywords: Heart failure with preserved ejection fraction, HFpEF, HFA-PEFF, H2FPEF, diagnostic scoring systems

Gurbet Özge Mert, Bülent Özlek, Eda Özlek, Hicaz Zencirkiran Ağuş, Mehmet Tekinalp, Serkan Kahraman, Cem Çil, Oğuzhan Çelik, Özcan Başaran, Volkan Doğan, Bedri Caner Kaya, İbrahim Rencüzoğulları, Altuğ Ösken, Lütfü Bekar, Mustafa Ozan Çakır, Yunus Çelik, Kadriye Memiç Sancar, Samet Sevinç, Murat Biteker, Kadir Uğur Mert. Comparing the Diagnostic Performance of HFA-PEFF and H2FPEF Scoring Systems in Heart Failure with Preserved Ejection Fraction Patients: Insights from the APOLLON Registry. Anatol J Cardiol. 2023; 27(9): 539-548

Corresponding Author: Gurbet Özge Mert, Türkiye
Manuscript Language: English


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