Objective: We aimed to evaluate serum adiponectin and C-reactive protein (CRP) levels in the different groups of patients with angiographically defined coronary artery disease (CAD). Materials and Methods: Overall 100 patients (80 males, 20 females) with CAD (≥ 50% stenosis) and 45 controls (25 males, 20 females) with normal coronary arteries were included in this cross-sectional observational study. Gensini score was used for evaluation of the severity of coronary lesions on the angiogram. A relationship between Gensini score and serum CRP and adiponectin levels was evaluated by a logistic regression analysis. Results: Mean age of the patients (60.5±10.2 years) was significantly higher than of the controls (55.6±10.4 years, p=0.01). While serum adiponectin levels in CAD patients (2.1±1.2 µmg/dl) were significantly lower than in the controls (3.3±1.8 µmg/dl, p=0.01); serum CRP levels of the patients (2.8±1.5 mg/dl) were significantly higher than of the controls (0.9±0.4 mg/dl). Serum adiponectin and CRP levels were not significantly different between the CAD subgroups (p>0.05). Gensini score was related with serum CRP (odds ratio: 0.98, 95% CI: 1.05-1.35, p=0.01) and adiponectin levels (odds ratio: 1.15, 95% CI: 1.10-1.25, p=0.01) by a logistic regression analysis. Conclusion: While serum CRP levels are increased in CAD patients comparing with the controls; serum adiponectin levels are decreased significantly. Serum CRP and adiponectin levels are related to coronary lesions severity on the angiogram.