ISSN 2149-2263 | E-ISSN 2149-2271
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The Prognostic Impact of Pericardial Fluid Cytology in Malignant Pericardial Effusion [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(1): 41-46 | DOI: 10.14744/AnatolJCardiol.2022.2050

The Prognostic Impact of Pericardial Fluid Cytology in Malignant Pericardial Effusion

Burak Sezenöz1, Feriha Pınar Uyar Göçün2, Emrullah Kızıltunç1, Salih Topal1, Hüseyin Murat Özdemir1
1Department of Cardiology, Faculty of Medicine, Gazi University, Ankara, Türkiye
2Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Türkiye

Objective: Malignant pericardial effusion may affect almost 15 of the patients with underlying malignancies which deteriorates the prognosis. The prognostic significance of pericardial fluid cytology is under-represented in previous studies.
Methods: A total of 73 patients with symptomatic pericardial effusion treated with pericardiocentesis were included in this retrospective analysis. Macroscopic appearance, biochemical features, and cytological findings were obtained. Patients were divided into 3 groups: (i) without malignancy, (ii) with malignancy and negative cytology, and (iii) with malignancy and positive cytology. Survival data were searched via governmental death notification system.
Results: Mean age of the study group was 62 ± 15, and 54% (40) of the patients were female. On the cytological evaluation, 17 patients (23.3%) revealed positive cancer cytology, whereas 56 patients (76.7%) revealed negative cancer cytology. The median follow-up period was 840 days, and 34 patients (46.5%) died during follow-up. The survival rate of Group 3 was found to be significantly worse compared to Groups 1 and 2, no statistical difference was found between Groups 1 and 2 in terms of survival ( Group 1 vs. Group 2 P =.078; Group 1 vs. Group 3 P <.001; Group 2 vs. Group 3 P =.041).
Conclusion: Cytological evaluation is an important step in patients with malignant pericardial effusion. Positive pericardial fluid cytology indicates a poorer prognosis.

Keywords: Pericardial effusion, survival, prognosis

Burak Sezenöz, Feriha Pınar Uyar Göçün, Emrullah Kızıltunç, Salih Topal, Hüseyin Murat Özdemir. The Prognostic Impact of Pericardial Fluid Cytology in Malignant Pericardial Effusion. Anatol J Cardiol. 2023; 27(1): 41-46

Corresponding Author: Burak Sezenöz
Manuscript Language: English


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