ISSN 2149-2263 | E-ISSN 2149-2271
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Gender-Related Differences in Patients with Acute Heart Failure: Observation from the Journey Heart Failure—Turkish Population Study [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(11): 639-649 | DOI: 10.14744/AnatolJCardiol.2023.2971

Gender-Related Differences in Patients with Acute Heart Failure: Observation from the Journey Heart Failure—Turkish Population Study

Filiz Akyıldız Akçay1, Ümit Yaşar Sinan2, Dogaç Çağlar Gürbüz3, Özgen Şafak4, Hakkı Kaya5, Ümit Yüksek6, Mehdi Zoghi7
1Department of Cardiology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Türkiye
2Department of Cardiology, Faculty of Medicine, İstanbul University Cerrahpaşa Institute of Cardiology, İstanbul, Türkiye
3Department of Cardiology, Faculty of Medicine, Koç University, İstanbul, Türkiye
4Department of Cardiology, Faculty of Medicine, Balıkesir University, Balıkesir, Türkiye
5Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye
6Department of Cardiology, Ödemiş State Hospital, İzmir, Türkiye
7Department of Cardiology, Faculty of Medicine, Ege University, İzmir, Türkiye

Background: Gender-related clinical variations in patients with acute heart failure have been described in previous studies. However, there is still a lack of research on gender differences in patients hospitalized for acute heart failure in Türkiye. The aim of this study is to compare the clinical features, in-hospital approaches, and outcomes of male and female patients hospitalized for acute heart failure.

Methods: Differences in clinical characteristics, medication prescription, hospital management, and outcomes between males and females with acute heart failure were investigated from the Journey Heart Failure—Turkish Population study.

Results: Nine hundred eighteen patients (57.2%) were men and 688 (42.8%) were women. Women were older than men (70.48 ± 13.20 years vs. 65.87 ± 12.82 years; P <.001). The frequency of comorbidities such as hypertension (72.7% vs. 62.4%, P <.001), diabetes (46.5% vs. 38.5%, P = .001),  atrial  fibrillation  (46.5%  vs.  33.4%,  P <.001), New York Heart Association class III-IV symptoms (80.6% vs. 71.2%, P =.001), and dyspnea in the rest (73.8% vs. 68.3%, P =.044) were more common in women on admission. Male patients were more frequently hospitalized with reduced left ventricular ejection fraction (51.0% vs. 72.4%, P <.001). In-hospital mortality was higher among female patients (9.3% vs. 6.4%, P =.022). Higher  New  York  Heart  Association  class,  lower  estimated  glomerular  filtration  rate, higher N-terminal pro-B type natriuretic peptide on admission, and mechanical ventilation usage were the independent parameters of in-hospital mortality, whereas the female gender was not.

Conclusion: Our study clearly demonstrated the diversity in presentation, management, and in-hospital outcomes of acute heart failure between male and female patients. Although left ventricular systolic functions were better in female patients, in-hospital mortality was higher. Recognizing these differences in the management of heart failure in different sexes will serve better results in clinical practice.

Keywords: Heart failure, acute heart failure, gender differences

Filiz Akyıldız Akçay, Ümit Yaşar Sinan, Dogaç Çağlar Gürbüz, Özgen Şafak, Hakkı Kaya, Ümit Yüksek, Mehdi Zoghi. Gender-Related Differences in Patients with Acute Heart Failure: Observation from the Journey Heart Failure—Turkish Population Study. Anatol J Cardiol. 2023; 27(11): 639-649

Corresponding Author: Filiz Akyıldız Akçay, Türkiye
Manuscript Language: English


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